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Quantitative risk evaluation method and system based on combined action of mixed benzene series

A technology of risk assessment and joint action, applied in the field of occupational health and occupational disease control, can solve the problem of underestimation of the risk of mixed benzene series

Active Publication Date: 2022-06-03
天津渤化讯创科技有限公司 +1
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Problems solved by technology

Therefore, the risk of mixed benzene series may be underestimated if combined effects are not considered

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  • Quantitative risk evaluation method and system based on combined action of mixed benzene series
  • Quantitative risk evaluation method and system based on combined action of mixed benzene series
  • Quantitative risk evaluation method and system based on combined action of mixed benzene series

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Embodiment Construction

[0016] It should be noted that the embodiments of the present invention and the features of the embodiments may be combined with each other under the condition of no conflict.

[0017] 1. The quantitative risk assessment method based on the combined action of mixed benzene series compounds proposed by the present invention specifically includes:

S1. Establish an inhalation PBPK model for exposure to mixed benzene series:

S101. Select an inhalation PBPK model exposed to mixed benzene series, and establish a binary interaction between benzene series (B: benzene, T: toluene, E: ethylbenzene, X: m-xylene) in the selected PBPK model, using for simulating the kinetics and intra-tissue exposure doses of mixed components. The binary interaction described here is reflected in the effect of the combined action of each benzene series on its metabolism, so what is actually to be established is the metabolic rate formula of each benzene series substance under the binary interaction. Th...

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Abstract

The invention provides a quantitative risk evaluation method and system based on the combined action of mixed benzene series, and the method comprises the steps: achieving internal exposure evaluation based on an inhalation PBPK model of mixed benzene series exposure; carrying out carcinogenic risk evaluation by using a multi-order model based on internal exposure evaluation; based on the internal exposure assessment, a risk index HI is used for non-carcinogenic risk assessment. The technical problem of simulation of metabolism of the mixed benzene series in a human body is solved; on the basis of considering the joint effect, quantitative health risk evaluation of mixed benzene series exposure is realized.

Description

technical field [0001] The invention belongs to the field of occupational health and occupational disease control, and particularly relates to a quantitative risk assessment method and system based on the combined action of mixed benzene series compounds. Background technique [0002] The organic solvent widely used in industry is usually a mixture of single or multiple components of benzene, toluene, m-xylene and ethylbenzene. Due to the metabolic inhibition between the mixed benzene series, the toxic metabolism of each substance in the mixed exposure scenario may be different from that in the single exposure scenario. At present, there is no technology to evaluate the metabolism of mixed benzene series compounds in the human body under the combined action. Since benzene, toluene, m-xylene, ethylbenzene and other substances may all cause central nervous system (CNS) damage, the combined risk of this health effect is not lower than the risk of a single substance due to meta...

Claims

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Application Information

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IPC IPC(8): G06Q10/06G16H50/30
CPCG06Q10/0635G16H50/30
Inventor 李敏嫣张倩黄德寅温冀鹏王志东殷伊琳
Owner 天津渤化讯创科技有限公司
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