Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of PU.1 inhibitor DB2313

1. The technology of PU.1 and inhibitors, which is applied in the field of application of DB2313, a potential therapeutic drug for rheumatoid arthritis, and can solve problems such as adverse reactions

Pending Publication Date: 2022-06-07
ANHUI MEDICAL UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no cure for RA, but its clinical manifestations can be improved to a certain extent through drugs such as non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs and biological agents, but long-term use of most drugs will cause severe Adverse reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of PU.1 inhibitor DB2313
  • Application of PU.1 inhibitor DB2313
  • Application of PU.1 inhibitor DB2313

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the invention. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0014] It should be noted that the terminology used herein is for the purpose of describing specific embodiments only, and is not intended to limit the exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural as well, furthermore, it is to be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates that There are features, steps, operations, devices, components and / or combinations thereof.

[0015] As described in the background art, the current treatment of rheumatoid arthritis often requires...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of a PU.1 inhibitor DB2313, DB2313 is used as an active component to prepare a medicinal preparation, and the medicinal preparation can simultaneously realize immune function regulation and inflammatory symptom improvement. Researches prove that the compound DB2313 can effectively improve the toe swelling degree and the arthritis index of mice with collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA), recover immune balance, reduce synovial hyperplasia, inflammatory cell infiltration and cartilage and bone destruction phenomena, reduce knee joint blood flow signals, improve inflammatory symptoms of a disease model, and can be used for preparing a medicine for treating osteoporosis. The compound can be used as a potential therapeutic drug for rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to the use of a PU.1 inhibitor DB2313, which can be used as a potential therapeutic drug for rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by synovial hyperplasia and infiltration of different cell types into the joint synovium. At present, there is no cure for RA, but the clinical manifestations of RA can be improved to a certain extent through drugs such as non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biological agents. Adverse reactions. Therefore, finding new key mechanisms of RA pathogenesis will provide experimental basis for the development of new therapeutic drugs with good curative effect and few adverse reactions. PU.1 is a member of the E26 transformation-specific transcription factor family an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4184A61P19/02A61P29/00A61P37/02
CPCA61K31/4184A61P19/02A61P29/00A61P37/02
Inventor 魏伟涂佳杰方亦龙陈维乐李真宝
Owner ANHUI MEDICAL UNIV
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement