Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia

A technology of clozapine and nitrogen anesthesia, which is applied in the field of medicine, can solve problems such as central nervous system dysfunction, diving diseases or diving accidents, and affect the safety of diving operations, so as to achieve quick results, alleviate and improve the symptoms of central nervous system hyperexcitability, Improvement of neurobehavioral symptoms

Active Publication Date: 2022-06-28
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, during the diving process, if nitrogen anesthesia occurs, it will cause central nervous system dysfunction, easily lead to other diving diseases or diving accidents, affect the safety of diving operations, and even lead to more serious consequences
However, there are currently no drugs for this

Method used

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  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia
  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia
  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia

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specific Embodiment

[0019] N-Clozapine can significantly improve the abnormal state of central nervous system in nitrogen anesthetized mice

[0020] (1) Control group: 0.1 ml of normal saline was injected into the mouse intraperitoneal cavity. After 30 minutes, the mice were placed in a hyperbaric chamber with air or nitrogen-oxygen mixture to pressurize to a pressure of 200 m to simulate the abnormal excitation symptoms of the nitrogen anesthesia center in divers. The voluntary movement trajectories of the mice were recorded and the distance of movement was analyzed to evaluate the severity of the central hyperexcitability of the mice.

[0021] (2) N-Clozapine Oxide treatment group: inject 0.2mg / kg, 1mg / kg, 1.5mg / kg, 2mg / kg of N-Clozapine Oxide into mice intraperitoneally, 30 minutes later, placed under high pressure The cabin was pressurized to a pressure of 200 m with air or nitrox, and the abnormal state of the central nervous system of the mice was evaluated by recording the voluntary moveme...

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Abstract

The invention belongs to the field of medicines, and discloses application of N-clozapine oxide in preparation of a medicine for preventing and treating nitrogen anesthesia. The N-clozapine oxide is given through the abdominal cavity, so that the abnormal central excitation symptom occurring in the diving process of compressed air or nitrogen-oxygen mixed gas can be improved, and the N-clozapine oxide has the advantages of being quick in effect taking, obvious in effect, convenient to use and the like. As the N-clozapine oxide is a metabolite of a clinically common medicine clozapine, the clinical popularization risk of the invention is low.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new use of Clozapine N-oxide (N-clozapine oxide), in particular to the application of N-clozapine oxide in the preparation of a medicine for preventing and treating nitrogen anesthesia. Background technique [0002] Nitrogen narcosis is a pathophysiology characterized by emotional, intellectual, and cognitive impairments, as well as motor and sensory impairments, when diving with compressed air or nitrogen-oxygen mixtures to a depth of 30 m or greater. state. Since this state is similar to the clinical application of general anesthesia or drunkenness, it is called nitrogen anesthesia. Nitrogen anesthesia recovers quickly after being released from the high-pressure nitrogen environment, and generally does not cause serious harm to human health and life. However, in the course of diving, if nitrogen anesthesia occurs, it will cause dysfunction of the central nervous system, easil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5513A61P25/00
CPCA61K31/5513A61P25/00Y02A50/30
Inventor 彭彬高永静
Owner NANTONG UNIVERSITY
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