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Application of deubiquitinating enzyme USP45 in preparation of medicine for treating lung squamous cell carcinoma

A deubiquitinase, lung squamous cell carcinoma technology, applied in the field of biomedicine, can solve problems such as no research revealing the mechanism of USP45

Pending Publication Date: 2022-07-01
NANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no research to reveal the mechanism of action of USP45 in tumorigenesis and development

Method used

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  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating lung squamous cell carcinoma
  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating lung squamous cell carcinoma
  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating lung squamous cell carcinoma

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Embodiment Construction

[0021] The features and advantages of the present invention can be further understood from the following detailed description in conjunction with the accompanying drawings. The description is an explanation of the content of the invention and does not in any way limit the rest of the disclosure of the invention.

[0022] The basis for supporting the content protected by the present invention is given below.

[0023] 1. Experimental methods and experimental operations

[0024] 1. Bioinformatics analysis

[0025] Normalized RNA-Seq data for lung squamous cell carcinoma were downloaded from the TCGA database via UCSC Xena (https: / / xena.ucsc.edu / ). RNA-Seq data of human normal tissues were downloaded from the GTEx database (https: / / commonfund.nih.gov / GTEx). We further extracted the expression data of ENSG00000123552 (USP45) gene in each sample according to the filtering principle of normal solid tissue, primary solid tumor, primary tumor and normal tissue. Then, log2(x+1) tran...

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Abstract

The invention discloses application of deubiquitinating enzyme USP45 in preparation of a medicine for treating lung squamous cell carcinoma, and belongs to the technical field of biological medicine. The mRNA expression level of the USP45 in the lung squamous cell carcinoma tissue is up-regulated and is in negative correlation with the recurrence-free lifetime of a lung squamous cell carcinoma patient, and the protein expression level of the USP45 in the lung squamous cell carcinoma tissue is increased; the USP45 knock-down can significantly inhibit the proliferation of lung squamous carcinoma cells. The invention provides application of USP45 serving as a lung squamous cell carcinoma molecular diagnosis marker or a prognosis prediction marker and application of USP45 serving as a target spot in preparation of a medicine for treating lung squamous cell carcinoma.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of deubiquitinating enzyme USP45 as a proliferation regulation molecule of lung squamous cell carcinoma and USP45 as a target in preparing a drug for treating lung squamous cell carcinoma. Background technique [0002] According to the latest tumor epidemiological survey results in my country, there were 3.929 million new tumor cases and 2.338 million deaths in 2015, including 787,000 new lung cancer cases and 630,000 lung cancer deaths. For example, its morbidity and lethality rank first among all tumors. The pathological types of lung cancer mainly include non-small cell lung cancer and small cell lung cancer. Non-small cell lung cancer accounts for about 80%-85% of lung cancer, and can be further divided into lung adenocarcinoma, lung squamous cell carcinoma, large cell carcinoma and so on. Among them, squamous cell carcinoma of the lung, also known as squ...

Claims

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Application Information

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IPC IPC(8): C12N9/48C12Q1/6886G01N33/574A61K45/00A61P35/00
CPCC12N9/48C12Q1/6886G01N33/57423G01N33/57484A61K45/00A61P35/00C12Q2600/118C12Q2600/178C12Q2600/158G01N2800/52Y02A50/30
Inventor 李凯王倩卞华段培培杜瑞娟
Owner NANYANG INST OF TECH