Chip

Abstract

The upper end of a through hole in the middle of a main body is connected with a top cover through a sealing layer capable of being opened, a plurality of flow channels are formed in the periphery of the through hole, the two ends of each flow channel are communicated with the through hole and a reaction chamber respectively, a storage part is hollow, a protruding part is arranged at the upper end of the storage part, and a sample adding opening is formed in the upper end of the protruding part; a plurality of liquid inlet holes are formed in the lower portion of the side wall of the storage part, the storage part is located in the through hole, the top cover blocks the upper end of the through hole before detection, part of the outer wall of the storage part is in transition fit with the inner wall of the through hole, the liquid inlet holes can be blocked through the inner wall of the through hole, and the storage part can move upwards along the through hole to eject the top cover open and is in a communicated state. In the communication state, a to-be-detected sample can be added into the storage part through the sample adding opening, the liquid inlet hole is communicated with the flow channel, and the to-be-detected sample and the detection reagent in the storage part can flow into the reaction chamber through the flow channel to react. The chip has a good sealed storage condition, and is high in detection precision, simple to operate and suitable for automatic detection.

Description

technical field [0001] The present invention relates to the technical field of nucleic acid detection, in particular to a chip. Background technique [0002] Microfluidics, also known as microfluidic chip technology, can integrate basic operation units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes into a chip of several square centimeters to control Fluids run through the entire system to replace various functions of conventional chemical or biological laboratories. It has the advantages of light weight, small amount of samples and reagents, low energy consumption, fast reaction speed, parallel processing in large quantities, and disposables. At present, microfluidics has great development potential and broad application prospects in biomedical research (such as nucleic acid detection). [0003] Aerosol refers to a gaseous dispersion system composed of solid or liquid particles suspended in a gas medi...

AI Technical Summary

Problems solved by technology

[0004] Chips are widely used in the field of nucleic acid detection. The existing chips usually pre-embed freeze-dried detection reagents in the reaction chamber of the chip. Since there are generally multiple reaction chambers on the chip, the embedding of the detection reagents is time-consuming and laborious. It is conducive to the mass production of chips; at the same time, the freeze-dried detection reagents are easy to deteriorate due to moisture, oxidation, etc. Aerosol pollution will affect the accuracy of the next test result, so it is necessary to seal the produced chip, remove the seal of the sealed chip before using the chip, and seal the chip again before the detection reaction. The above operations need to be done manually , not easy to use in an automated detection system

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