Method for rapid colorimetric analysis of catecholamine based on MnCo-C NCs active material and application thereof

A technology of catecholamines and active materials, applied in the field of colorimetric sensing, can solve problems such as limiting wide application, and achieve the effects of simple preparation process, shortened detection time, good use value and market prospect

Pending Publication Date: 2022-07-05
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, obtaining nanomaterials with high catalytic activity is still a challenge, which greatly limits their wide application.

Method used

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  • Method for rapid colorimetric analysis of catecholamine based on MnCo-C NCs active material and application thereof
  • Method for rapid colorimetric analysis of catecholamine based on MnCo-C NCs active material and application thereof
  • Method for rapid colorimetric analysis of catecholamine based on MnCo-C NCs active material and application thereof

Examples

Experimental program
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Embodiment 1

[0034] A method for rapid colorimetric analysis of catecholamines based on MnCo@C NCs active materials, including the following steps:

[0035] (1) Preparation of MnCo@C NCs:

[0036] (1.1) manganese acetate, PVP are dispersed in ethanol and water mixed solution and stir, subsequently, add cobalt potassium cyanide aqueous solution, the mass ratio of manganese acetate and PVP is 1: 6, and the mol ratio of Mn and Co element is 1: 1. Incubate at room temperature to obtain MnCo precursor;

[0037] (1.2) redispersing the prepared MnCo precursor into an aqueous solution, then adding an aqueous dopamine solution, the mass ratio of dopamine and MnCo precursor is 1:1, to obtain a polydopamine-coated MnCo precursor;

[0038] (1.3) The polydopamine-coated MnCo precursor obtained in step (1.2) is subjected to high temperature pyrolysis to obtain MnCo@CNCs nanomaterials. like figure 1 As shown, the electron microscope imaging analysis of MnCo@C NCs shows that MnCo@C NCs have a regular h...

Embodiment 2

[0048] Example 2

[0049] Wherein, in step (1), the mass ratio of manganese acetate to PVP is 1:10, and the molar ratio of Mn to Co is 1:3, and incubated at room temperature to obtain MnCo precursor; the mass ratio of dopamine to MnCo precursor is 1:3.

[0050] The rest are the same as in Example 1.

[0051] It should be noted that the properties of the MnCo@CNCs prepared in Example 2 are the same as those of the MnCo@CNCs prepared in Example 1, and they also have good catalytic activity for epinephrine.

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Abstract

The invention discloses a method for rapid colorimetric analysis of catecholamine based on a MnCo-C NCs active material and application of the method, and belongs to the technical field of colorimetric sensing. The method comprises the following steps: firstly preparing a MnCo-C NCs active material with a core-shell structure, adding MnCo-C NCs into a plurality of morpholine ethanesulfonic acid buffer solution samples containing catecholamine with different concentrations by utilizing the high catalytic activity of the MnCo-C NCs active material, reacting, and recording the absorbance value A of each sample at the wavelength of 485 nm after the reaction to obtain a detection linear relationship between the catecholamine concentration and the absorbance value A; and analyzing the concentration of catecholamine in the to-be-detected sample according to the detection linear relation and the absorbance value of the catecholamine-containing to-be-detected sample. The colorimetric detection method has the advantages of low cost, simplicity and convenience in operation, quick response, high sensitivity and the like, and can be applied to human health diagnosis.

Description

technical field [0001] The invention belongs to the technical field of colorimetric sensing, and relates to a colorimetric analysis method for catecholamines, in particular to a method for rapid colorimetric analysis of catecholamines based on MnCo@C NCs active materials and its application in human health diagnosis. Background technique [0002] Catecholamines are a class of biogenic compounds, including dopamine, epinephrine, and norepinephrine, which play important physiological roles in the human body as neurotransmitters and hormones, and are also important markers for diagnosing diseases and dysfunctions, such as paroxysmal Kinson's disease, schizophrenia, and Alzheimer's disease, among others. Therefore, the determination of catecholamines in human body is of great significance to the diagnosis of diseases and the study of pathophysiological mechanisms. At present, the methods for their determination include: high performance liquid chromatography, liquid chromatogra...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): G01N21/31G01N21/78G01N21/29B01J23/889
CPCG01N21/31G01N21/78G01N21/29B01J23/002B01J23/8892B01J35/397
Inventor汤琳朱旭陈丽卢雅婷
OwnerHUNAN UNIV