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Application of 8-isoprostaglandin F2alpha in diagnosis of severe asthma

A technology for isoprostaglandin and severe asthma, applied in the field of biomedical detection, can solve the problems of peroxidative damage products, aggravating tissue damage and morphological changes, affecting signal transmission, etc.

Pending Publication Date: 2022-07-05
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Biomembranes widely exist in the body, and lipids are easily attacked by free radicals, resulting in the production of peroxidative damage products
The peroxidation reaction of membrane lipids will lead to fatty acid chain breakage, aggravate airway inflammatory response, cause tissue damage and morphological changes, and at the same time change the fluidity and permeability of biomembranes, resulting in its dysfunction and affecting signal transmission
However, there is no relevant report on the use of 8-isoprostane F2α as a diagnostic marker for severe asthma

Method used

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  • Application of 8-isoprostaglandin F2alpha in diagnosis of severe asthma
  • Application of 8-isoprostaglandin F2alpha in diagnosis of severe asthma

Examples

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Embodiment

[0020] This example provides the application of 8-isoprostaglandin F2α in the diagnosis of severe asthma:

[0021] The plasma and induced sputum supernatants were collected from the recruited severe and non-severe asthma patients, and 8-iso-PGF2α was detected by ELISA. The results showed that the concentrations of 8-iso-PGF2α in peripheral blood (162.41±307.32vs.61.39±58.78, P=0.057) and induced sputum (239.92±234.13vs.106.39±97.78, P=0.022) of patients with severe asthma were higher than those in non- For patients with severe asthma, the specific data are shown in Table 1. In order to further evaluate the effect of 8-iso-PGF2α concentration on pulmonary function in asthma patients, we detected the pulmonary function indexes of asthma patients, and performed linear regression on the 8-iso-PGF2α concentration in peripheral blood and induced sputum of asthma patients and pulmonary function parameters. It showed that the concentration of 8-iso-PGF2α in induced sputum was negativ...

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Abstract

The invention discloses an application of 8-isoprostaglandin F2alpha in diagnosis of severe asthma. The invention provides an application of 8-isoprostaglandin F2alpha as a biomarker in preparation of a product for diagnosis or auxiliary diagnosis of severe asthma, which comprises the following steps: detecting the concentration of 8-isoprostaglandin F2alpha in plasma and induced sputum supernatant of an asthma patient; the concentration of 8-isoprostaglandin F2alpha is found to have significant difference in detection samples of severe asthma patients (SA) and non-severe asthma patients (NSA), and meanwhile, by detecting lung function indexes of the asthma patients, the concentration of 8-isoprostaglandin F2alpha in the detection samples is found to have a negative correlation trend with the lung function indexes; the biomarker 8-iso-PGF2 alpha provided by the invention can be conveniently detected through ELISA (Enzyme-Linked Immunosorbent Assay), and the severe asthma can be diagnosed in a simpler and more convenient manner.

Description

technical field [0001] The invention relates to the application of 8-isoprostaglandin F2α in the diagnosis of severe asthma, and belongs to the technical field of biomedical detection. Background technique [0002] The diagnosis of severe asthma is carried out according to the expert consensus of GINA and the asthma group of the Respiratory Branch of the Chinese Medical Association. Generally, the disease control can only be achieved by the application of grade 4 or 5 anti-asthma treatment or the disease is difficult to control once the treatment grade is lowered. Therefore, the judgment of severe asthma is generally delayed, and a period of follow-up observation of a specific patient is required to make an accurate diagnosis. [0003] 8-iso-prostaglandin F2α (8-iso-prostaglandin F2alpha, 8-iso-PGF2α) is derived from the free radical-catalyzed arachidonic acid peroxidation reaction, and its concentration can reflect the level of oxidative stress damage in the body, and is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/88
CPCG01N33/88G01N2800/122
Inventor 陈智鸿毛若琳闵智慧徐侃崔博朱振华
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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