Screening method of polypeptide compound and related device

A screening method and peptide compound technology, applied in the computer field, can solve the problems affecting the accuracy of peptide compounds, prone to errors, time-consuming and labor-intensive, etc., to achieve a fast and accurate activity screening process, improve accuracy, and ensure effectiveness Effect

Pending Publication Date: 2022-07-08
TENCENT TECH (SHENZHEN) CO LTD
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AI Technical Summary

Problems solved by technology

[0004] However, the method of artificially adding compound features is not conducive to the screening of a large number of peptide compounds, which is

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  • Screening method of polypeptide compound and related device
  • Screening method of polypeptide compound and related device
  • Screening method of polypeptide compound and related device

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[0125]The embodiments of the present application provide a method for screening polypeptide compounds and a related device, which can be applied to a system or program that includes a screening function for polypeptide compounds in terminal equipment, and obtains a polypeptide generation model by responding to a target instruction; and then generates a model based on the polypeptide. At least one polypeptide sequence is generated, and the polypeptide generation model includes an encoding layer and a decoding layer. The encoding layer is used to generate a latent space according to the training data, and the latent space is used to provide sampling points. The polypeptide sequence is obtained by decoding the sampling points based on the decoding layer; The activity prediction model is input to obtain the activity prediction information, and the activity prediction information is used to screen the target polypeptide in the polypeptide sequence. In this way, a rapid and accurate ...

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Abstract

The invention discloses a polypeptide compound screening method and a related device, and is applied to the field of artificial intelligence. A model is generated by obtaining polypeptide; then generating at least one polypeptide sequence based on a polypeptide generation model, the polypeptide generation model comprising a coding layer and a decoding layer, the coding layer being used for generating a hidden space according to the training data, the hidden space being used for providing sampling points, and the polypeptide sequence being obtained by decoding the sampling points based on the decoding layer; and inputting the polypeptide sequence into the activity prediction model to obtain activity prediction information. Therefore, a rapid and accurate polypeptide compound activity screening process is realized, the input of the activity prediction model adopts the polypeptide sequence obtained by sampling the feature dimension in the polypeptide generation model, the sampling effectiveness is ensured, manual operation is not needed, and the accuracy of polypeptide compound screening is further improved.

Description

technical field [0001] The present application relates to the field of computer technology, and in particular, to a screening method for polypeptide compounds and related devices. Background technique [0002] AI (Artificial Intelligence, artificial intelligence) is an emerging science and technology currently researched and developed for simulating, extending and expanding human intelligence. Nowadays, AI technology has been widely used in a variety of scenarios, such as the AI ​​medical scenario is one of them. [0003] Generally, in AI medical scenarios, the activity of antimicrobial peptides can be predicted based on artificial intelligence, and artificial compound features can be added for the prediction process to identify similar compounds. [0004] However, the method of artificially adding compound features is not conducive to the screening of a large number of polypeptide compounds, is time-consuming and labor-intensive, and the artificially added features are pro...

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Application Information

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IPC IPC(8): G16C20/30
CPCG16C20/30Y02A90/10
Inventor 叶阁焰刘伟黄俊洲
Owner TENCENT TECH (SHENZHEN) CO LTD
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