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Composition comprising a new microorganism with enhanced persistance, synergistic combination of

A technology of composition and synbiotics, applied in the field of formula

Pending Publication Date: 2022-07-08
NUTECH VENTURES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Despite the potential of the IVS approach for isolating indigenous synergistic strains with putative beneficial properties, the approach requires at least human individual studies

Method used

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  • Composition comprising a new microorganism with enhanced persistance, synergistic combination of
  • Composition comprising a new microorganism with enhanced persistance, synergistic combination of
  • Composition comprising a new microorganism with enhanced persistance, synergistic combination of

Examples

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Embodiment 1

[0070] In this example, stepwise in vitro fermentations were performed to enrich for strains capable of using XOS, and the most successful strains were identified and characterized.

[0071] method

[0072] Sample Collection

[0073] A total of 20 stool samples were collected from volunteers throughout the study period. Each participant was asked to sign a consent form stating that they had no known gastrointestinal disease, were 19 years of age or older, had not taken antibiotics or probiotic supplements in the past 6 months, were not a regular customer of yogurt, and Willing to provide 1-3 stool samples within three months. Participants were provided with a toilet specimen collection kit (Fisher Scientific, New Hampshire, USA) and detailed collection and preservation instructions. This study was approved by the UNL Institutional Review Board (IRB 20160616139).

[0074] In an anaerobic chamber (Bactron IV Anaerobic Chamber, Sheldon Manufacturing, Cornelius, OR USA, 5% H ...

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Abstract

A particularly effective prebiotic-probiotic combination is provided, as well as a method of identifying a synergistic probiotic-prebiotic combination, including the new probiotics Bifidobacterium longum subsp. Longum and XOS, as well as Bifidobacterium pseudocatenaria and xylooligosaccharide. In addition, the invention also provides a kit comprising the probiotics and the prebiotics.

Description

Background technique [0001] It is now generally accepted that the composition and function of the gastrointestinal microbiome play an important role in maintaining host health. How diet affects the human gut microbiome is one of the most important areas of research in food, nutrition and biomedical sciences. In particular, a disrupted or dysregulated microbiota is thought to contribute to a variety of gastrointestinal and systemic diseases. Researchers are now particularly interested in developing treatments or dietary approaches to correct or restore these imbalances. [0002] A common outcome of many biomedical reports and clinical trials is the observation that a specific treatment may be effective in some individuals but not in others. This responder / non-responder phenomenon is also common in trials using probiotics, prebiotics, and other gut health interventions. For example, while many clinical studies have shown that prebiotic supplements can induce a bifidobacterial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/745A61K31/702A61K47/36A61K9/19A61P1/00A23L33/135A23L33/21A23K10/18A23K20/163A23K50/30A23K50/10A23K50/40A23K50/75A23K50/70
CPCA61K35/745A61K31/702A61P1/00A61K2300/00A23L33/21A23L33/135A61K9/19A61K47/36A23V2400/533A23V2400/535
Inventor R·哈特金斯C·R·科科M·马尔多纳多-戈麦斯
Owner NUTECH VENTURES LTD