Preparation process of traditional Chinese medicine compound granules

A preparation process and granule technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of increasing solubility, increasing stability, and reducing odor
CN114748432AActive Publication Date: 2022-07-15GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Publication Date
2022-07-15

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Abstract

The invention discloses a preparation process of traditional Chinese medicine compound granules, which comprises the following steps: (1) adding water into isatis root, cape jasmine and honeysuckle flower, decocting, filtering decoction, and merging filtrate to obtain a triple-mixed extracting solution; (2) respectively grinding cornu bubali and nacre mother of pearl into powder, respectively decocting and filtering, combining filtrate, and carrying out inclusion by utilizing cyclodextrin to obtain mixed hydrolysate; (3) concentrating the three-mixed extracting solution and the mixed hydrolysate to obtain a five-mixed extract; (4) dispersing cholic acid and hyodeoxycholic acid by using mannitol to obtain mixed cholic acid dispersed powder or particles; (5) dispersing baicalin by using mannitol to obtain baicalin dispersed powder or particles; and (6) finally, uniformly mixing the five-mixed extract, the mixed cholic acid and the baicalin solid dispersion, adding auxiliary materials, drying, and preparing into granules. According to the new process, peculiar smell and bitter taste can be covered, the medication compliance of a patient is improved, and meanwhile the quality and stability of the Qingkailing granules are improved.
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Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine granules, and particularly relates to a preparation process of traditional Chinese medicine compound granules. Background technique

[0002] Chinese herbal medicines are made into traditional Chinese medicine forms such as pills, powders, pastes, and dan, but the disadvantages of large dosage, unstable quality and poor preservation have greatly restricted the development of Chinese medicine. The extraction and separation of active ingredients in Chinese herbal medicines is the key to improving the efficacy of traditional Chinese medicine, reducing adverse reactions and improving the internal quality of preparations. Chinese medicine granules refer to the solid preparations for oral administration prepared by extracting and concentrating medicinal materials with water or other solvents by suitable methods. It is a new dosage form developed and improved by using modern preparat...

Claims

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