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Compound traditional Chinese medicine granule for treating CVD

A compound traditional Chinese medicine and cardiovascular technology, which is applied to cardiovascular system diseases, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of large toxic side effects, accumulation of poisoning, and restricted use of attached tablets, and achieve continuous and significant clinical curative effect , reduce toxic and side effects, and increase the effect of supplementary tablet dosage

Inactive Publication Date: 2005-09-14
吴荣祖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, digitalis preparations are still the first choice for cardiotonic drugs in the clinical treatment of heart failure, and some need to be taken for a long time. Taking digoxin can lead to accumulation poisoning, which objectively restricts the use of this kind of medicine; the ancient prescription Zhenwu Decoction is derived from "Treatise on Febrile Diseases", which is composed of five flavors of aconite, Poria cocos, Atractylodes macrocephala, peony, and ginger. The effective prescription of Fuzi, Poria, Ginger, Paeoniae 9 parts each, and Atractylodes macrocephala 6 parts by weight. Due to the high toxicity and side effects of Fuzi, the dosage cannot be increased to affect the curative effect. Long-term use of Zhenwu decoction is very inconvenient for patients. , and due to the strong toxicity of the attached tablet, the lethal dose of its toxic components to humans is only 3-4mg, heating and decocting can reduce the toxicity, but the time and temperature are not easy to control, and the safety of medication is difficult to guarantee
[0003] The purpose of the present invention is to provide a method that not only avoids the consequences of accumulation and poisoning caused by long-term use of digitalis, but also overcomes the problem that it is difficult for patients to grasp the safety and inconvenience of medication when decocting attached tablets. A large dose of more than 4 times the amount of the attached tablet is reused, and the compound granule is made by scientific technology, which not only avoids the toxicity of the attached tablet but also enhances the clinical effect of the attached tablet, making it convenient for patients to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] 1. Use 40 kg of attached slices, 20 kg of ginger, add 480 dry grams of water (8 times) to reflux extraction, decoct three times, extract for 5 hours for the first time, filter, and use the filtrate for later use; Filtrate for 2 hours for the second time, and merge the filtrate for three times for subsequent use;

[0012] 2. 20 dry grams of Poria cocos, 10 kg of Atractylodes macrocephala, 10 kg of peony, add 320 kg of water (8 times) to reflux extraction, cook for 3 hours for the first time, filter for later use, cook for 2 hours for the second time, and use the filtrate for later use, and cook for 1 hour for the third time , the filtrate is for subsequent use, and the filtrates are combined three times;

[0013] 3. Combine the decocting solution of Fupian and ginger with the extract filtrate of Poria cocos, Atractylodes macrocephala and peony, concentrate under reduced pressure or normal pressure to form a paste, dry at 80°C, crush and add 80% ethanol to make a soft mat...

Embodiment 2

[0015] 1. Take 70 kg of attached slices from the same place of origin, 30 kg of ginger, add 1200 kg of water (12 times) to reflux extraction, extract three times, extract for 4 hours for the first time, and use the filtrate for later use; extract for the second time for 3 hours, and use the filtrate for later use; First extraction for 1 hour, filtrate, combined three times of filtrate for subsequent use;

[0016] 2. Take 3.5 kg of Poria cocos, 20 kg of peony, and 20 kg of Atractylodes macrocephala from the same place of origin, add 90 kg of water (12 times) to reflux and extract, filter for 2 hours for the first extraction, filter for 1 hour for the second extraction, and 1 hour for the third extraction Filter, and combine the three extracts for later use;

[0017] 3. Combine the extracts of Fupian and ginger with the extract filtrate of Poria cocos, peony, and Atractylodes macrocephala, concentrate under reduced pressure or normal pressure to form a paste, dry at 70°C, crush ...

Embodiment 3

[0019] 1. Take 100 kg of attached slices from the same place of origin, 40 kg of ginger, add 1960 kg of water (14 times) to reflux and extract three times, extract for the first time for 3 hours and filter, extract for the second time for 2 hours and filter, extract for the third time for 1 hour and filter, Merge the three filtrates for subsequent use;

[0020] 2. Take 50 kg of Poria cocos, 30 kg of peony, and 30 kg of Atractylodes macrocephala from the same place of origin, add 1540 kg of water (14 times) to reflux extraction, extract for the first time for 3 hours, filter, extract for the second time for 2 hours, and extract for the third time 1 Filter for 1 hour, and combine the three extracts for later use;

[0021] 3. Combine the extracts of Fupian and ginger with the extract filtrate of Poria cocos, peony, and Atractylodes macrocephala, concentrate under reduced pressure or normal pressure to form a paste, dry at 80°C, crush and pass through a 100-mesh sieve to obtain a ...

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PUM

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Abstract

The compound Chinese medicine granular preparation for curing angiocardiopathy is formed from five Chinese medicinal materials of aconite accessooy tuber, poria, peony root, ovate atractylodes root and ginger, and is characterized by that it can utilize a certain technical process to respectively extract the effective components of the above-mentioned raw materials, and the dosage of aconite accessory tuber can be increased and a certain preparation process is added to reduce its toxicity to 1 / 2000. Its compound Chinese medicine prescription is rigorous, and its preparation process is simple and reliable.

Description

1. Technical field [0001] The invention belongs to a herbal traditional Chinese medicine composition drug, in particular to a granule medicine made from a herbal traditional Chinese medicine as a raw material and a preparation method thereof. 2. Background technology [0002] Heart rate failure is a serious complication of many heart patients, and it is one of the important causes of disability and death in heart patients. Since heart failure itself is a critical, urgent, and severe disease in internal medicine, it seriously endangers the life of the patient or reduces the quality of life of the patient. At present, digitalis preparations are still the first choice for cardiotonic drugs in the clinical treatment of heart failure, and some need to be taken for a long time. Taking digoxin can lead to accumulation poisoning, which objectively restricts the use of this kind of medicine; the ancient prescription Zhenwu Decoction is derived from "Treatise on Febrile Diseases", wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/10
Inventor 吴荣祖
Owner 吴荣祖