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Transdermal administration of huperzine

A technology of huperzine and preparations, applied in the field of compositions for transdermal administration of huperzine, can solve problems such as frequent medication

Inactive Publication Date: 2006-02-08
AMERICAN EXEL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many ways to treat patients with memory loss and cognitive impairment, such as oral administration, but one of the difficulties is the need for frequent medication

Method used

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  • Transdermal administration of huperzine

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0038] The terms "matrix", "matrix system" or "matrix patch" used herein refer to dissolving or suspending a certain amount of huperzine in a polymer carrier or in a phase. Drugs or other health beneficial substances are dissolved or suspended in the pressure sensitive adhesive. This definition is meant to include embodiments where such polymeric phases are laminated to pressure sensitive adhesives, or where adhesives are used to make adhesive matrix-type patches with depots. These matrix patches usually consist of an adhesive layer with an impermeable backing film on the outside and a release liner on the inside, which is to be removed before use. The backing film is the polymeric phase that protects the backbone patch and prevents the delivery of drugs and / or accelerators to the external environment. The release liner acts like a backing film, but is removed as described above prior to applying the adhesive matrix patch to the skin. These matrix patches, which are known in...

Embodiment 4

[0128] Preparation Four (1)

[0129] * A single Eudragit and a mixture of different levels of Eudragit. Eudragit can be selected from: NE30D, L100, L12 / 5, S100, S12 / 5, L30D-55, E100, E12 / 5, RL100, RL12 / 5, R100, RL PO, PL PM, RL 30D, RS100, RS 12 / 5, RS PM, RS PO, RS30D, etc.

Embodiment 5

[0132] GMO: Glyceryl Monooleate

[0133] LA: lauryl alcohol

[0134] L-DEA: Lauramide Diethanolamine (Lauromide DEA)

[0135] * (mean ± SD), n = 3 skin donors, 12 diffusion cells

[0136] The test results show that penetration enhancers can increase the rate of penetration of huperzine A from the gel formulation through the skin. The gel formulation may be suitable for topical administration or as a depot patch.

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PUM

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Abstract

The present invention provides a composition of transdermally administered huperzine for improving memory and cognitive function. In one aspect, huperzine is delivered in a sufficient amount to achieve and maintain a blood plasma Huperzine level of about 0.1 ng / mL to about to 30 ng / mL. Huperzine may be delivered by itself, or in combination with other positive health promoting substances, such as vitamins, minerals, other cholinesterase inhibitors, etc. Various formulations for the transdermal delivery of huperzine are disclosed, and may include selected penetration enhancers.

Description

technical field [0001] The present invention mainly relates to compositions and methods capable of improving human memory and cognitive functions. More specifically, the present invention relates to a composition and method for transdermally administering huperzine capable of achieving an ideal blood concentration. Background of the invention [0002] Good memory and cognitive function are very important for a person's self-reliance and self-care. It is an important part of a person's quality of life. In general, people with excellent memory and cognitive skills are highly productive and successful academically and professionally, while people who think clearly and act decisively tend to have good social skills. [0003] Many people benefit from good memory and cognitive skills, and many aspire to improve these abilities. In addition, those who suffer from cognitive and memory dysfunction are suffering. They cannot communicate with society normally, cannot participate in s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/44A61K31/4748A61K45/06A61K9/70A61P25/00A61K47/06A61K47/10A61K47/14A61K47/18A61K47/26
CPCA61K31/4748A61K47/06A61K9/7069A61K9/7061A61K9/7053A61K47/26A61K9/0014A61K47/18A61K47/14A61K47/10A61K31/44A61K45/06A61P25/00A61K31/00A61K2300/00
Inventor 熊伟弘狄奈希·C·帕泰尔
Owner AMERICAN EXEL PHARM CO LTD
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