Medicinal preparation containing erythromycine ethylsuccinate

A technology of erythromycin ethylsuccinate and pharmaceutical preparations, applied in the directions of medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulations, etc., can solve the problem of successful development of parenteral administration formulations of erythromycin ethylsuccinate. and other problems, to achieve the effect of rapid curative effect, high safety and wide application

Inactive Publication Date: 2006-06-14
MICROBIOLOGY INST OF SHAANXI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no relevant literature and product reports on the successful development of parenteral dosage forms of erythromycin ethylsuccinate

Method used

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  • Medicinal preparation containing erythromycine ethylsuccinate
  • Medicinal preparation containing erythromycine ethylsuccinate

Examples

Experimental program
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Effect test

Embodiment Construction

[0017] In the following examples, hydroxypropyl beta cyclodextrin has an average degree of substitution of hydroxypropyl groups per cyclodextrin molecule of 5.5. The prepared medicaments are all water-soluble powders for intravenous administration or intramuscular administration of erythromycin ethylsuccinate.

[0018] component

[0019] Add hydroxypropyl beta-cyclodextrin to 5ml of water under stirring conditions, and continue to stir until it is completely dissolved; add ethylsuccinate and stir until it is completely dissolved; microwave treatment in an ice bath for 2 minutes; the resulting solution is sterilized with 0.2 mm nylon membrane filter; add medicinal glucose powder, stir until dissolved; after freeze-drying, it can be packaged and used.

[0020] component

[0021] Add hydroxypropyl beta-cyclodextrin to 5ml of medicinal absolute ethanol under stirring conditions, and continue to stir until completely dissolved; add ethylsuccinate and stir until ...

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PUM

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Abstract

A pharmaceutical preparation containing erythromycin ethylsuccinate. The preparation of the invention comprises erythromycin ethylsuccinate and hydroxypropyl beta cyclodextrin, the weight ratio of which is 1:1-1:50. The preparation is in the form of water-soluble powder, suitable for parenteral administration, such as intravenous administration or intramuscular administration. Due to the good water solubility and excellent encapsulation of cyclodextrin derivatives, erythromycin ethylsuccinate is soluble in water, and the stability of erythromycin ethylsuccinate-cyclodextrin derivatives complex in water can be further improved by freeze-drying, Control and reduce the decomposition of erythromycin ethylsuccinate. The invention has the advantages of simple preparation, stable performance, high safety, low side effects, rapid curative effect and wide application; it solves the disadvantage that the current erythromycin containing ethylsuccinate can only be administered through intestinal tract alone.

Description

technical field [0001] The invention belongs to the improvement of the dosage form of erythromycin containing ethylsuccinate, and relates to the technical field of medicine. Background technique [0002] Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate) chemical name erythromycin 2'-ethyl succinate; molecular formula: C 43 h 75 NO 16 , Molecular weight: 862.07, belonging to macrolide antibiotics, is a new generation of broad-spectrum antibacterial anti-inflammatory drugs, has been included in the US Pharmacopoeia, European Pharmacopoeia and Chinese Pharmacopoeia (2000 edition). Its greatest feature is its broad antibacterial spectrum and wide range of medication, and is suitable for various inflammations, especially for patients with allergies and drug resistance to penicillins and cephalosporins. Ethrythromycin ethylsuccinate has definite curative effect and rapid action, especially for upper respiratory tract infections caused by atypical pathogens such as Legio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/14A61K47/40A61P31/04
Inventor 杨国武李皎汪大敏赵兰云刘清利
Owner MICROBIOLOGY INST OF SHAANXI
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