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Carboxymethyl chitin membrane for postoperative adhesion prevention and its preparation method

A carboxymethyl chitin and anti-adhesion technology, applied in the field of medical supplies, can solve the problems of poor adhesion between chitosan film and tissue, inconvenient for clinical operation and use, etc., and achieves soft mechanical strength, good anti-adhesion effect, and biological good compatibility

Inactive Publication Date: 2006-06-28
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Journal of Biomedical Engineering, 1998, 15(2): 183-185), at the same time, chitosan film has poor adhesion to tissue, which is not convenient for clinical operation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] (1) Preparation of carboxymethyl chitin: Take 10g of purified chitin powder, put it in a glass three-necked flask, add isopropanol or ethanol under stirring, the weight ratio of chitin to isopropanol or ethanol is 1:15~ 20. Add NaOH or KOH, the molar ratio of which to chitin is 3-10:1, stir and alkalize for 6-24 hours. Slowly add chloroacetic acid under stirring, the molar ratio of it to chitin is 2-5:1, and stir for 8-24 hours. After the reaction, the solid was separated from the liquid, and the solid was washed with alcohol solution. Dissolve the solid in water to form a colloidal solution, adjust the pH to neutral with an acid solution, remove the insoluble matter by filtration, add ethanol to precipitate the solution while stirring, and separate the solid from the liquid. Repeat water dissolution and filtration, ethanol precipitation, solid-liquid separation, and dry the solid to obtain purified carboxymethyl chitin. The carboxymethylation degree of the carboxyme...

Embodiment 2

[0016] (1) Preparation of colloidal solution of carboxymethyl chitin and chitosan: take by weighing carboxymethyl chitin and chitosan prepared in Example 1, their weight ratio can be: 1: 0.1~10, put into In the beaker, add 100ml of acidic aqueous solution, stir to dissolve, and make a mixed colloid solution of carboxymethyl chitin and chitosan with a concentration of 1% to 5% by weight, filter with a sand core funnel to remove trace insolubles, and obtain clear and transparent Colloidal solution, stand still or vacuum degassing. The deacetylation degree of the used chitosan is more than 70%, and the molecular weight range is 50KD-600KD. The acidic aqueous solution used may be an aqueous solution of acetic acid, formic acid or hydrochloric acid, and its weight percent concentration is 0.5%-5%.

[0017] (2) Membrane production: Take a clean glass plate, stainless steel plate or polystyrene plate, adjust the level, pour the mixed solution of carboxymethyl chitin and chitosan on ...

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PUM

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Abstract

A post operation adhesion proof carboxymethyl chitin membrane characterizing in containing carboxymethyl chitin and cross linking agent or chitosan is provided. The weight ratio of carboxymethyl chitin with cross linking agent is 100:0.1-0.5, while the weight ratio of carboxymethyl chitin with chitosan is 100:10-1000. The preparing process: carboxy methylating chitin to carboxymethyl chitin, combining with cross linking agent or chitosan to prepare carboxy methylating chitin water soluble collagen solution or acid solution, preparing to carboxy methylating chitin dry membrane, flushing and drying. The adhesion proof membrane provided by the invention has favorable tissue compatibility, favorable adhesion with body wound surface, rapid degradation rate, in addition, the degradation product can be absorbed and utilized by body without adverse reaction.

Description

[0001] Technical solutions [0002] The invention relates to a medical product, in particular to a postoperative anti-adhesion degradable carboxymethyl chitin film and a preparation method thereof. Background technique [0003] Postoperative adhesions are a common complication in surgical operations, with an incidence rate as high as 90%. Postoperative adhesions can lead to severe clinical symptoms, such as abdominal pain, pelvic pain, intestinal obstruction, etc., causing great pain to patients, so postoperative adhesions are an urgent problem to be solved. At present, there are two main types of postoperative adhesion prevention measures clinically: one is to use drugs for adjuvant therapy, such as antibiotics, anti-inflammatory drugs, anticoagulants, etc. Not ideal, and some drugs have obvious side effects; the second is to use spacers, such as colloidal solutions of hyaluronic acid, dextran, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyethylene glycol, etc., b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/08
Inventor 韩宝芹刘万顺陈列欢
Owner OCEAN UNIV OF CHINA
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