Method for diagnosing and distinguishing stroke

A protein and marker technology, used in biochemical equipment and methods, disease diagnosis, analysis materials, etc., can solve problems such as increasing the risk of bleeding and side effects

Inactive Publication Date: 2002-03-06
SYN X PHARMA
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  • Abstract
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However, these drugs also carry the si...

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  • Method for diagnosing and distinguishing stroke
  • Method for diagnosing and distinguishing stroke
  • Method for diagnosing and distinguishing stroke

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Embodiment

[0052] A prospective observational pilot study was conducted in two tertiary hospitals. This study evaluated 33 patients with clinically and computed tomography (CT) diagnosis of acute ischemic stroke. The average age of stroke patients was about 66 years (66.4±16.4), and the age range was 27 to 90 years. The delay between onset of symptoms and transport to hospital averaged 22 hours, with a range of 1 to 72 hours. The Admission National Institutes of Health Stroke Scale and the Discharge modified Rankin scale scores were recorded. At one hospital, blood samples were obtained on days 1, 3, 5, and 7 of illness, and at a second hospital on days 1, 2, and 3, all blood samples were centrifuged, and aliquots of serum were refrigerated in- 80°C until used for analysis of S100, NSE, MBP and Tm.

[0053] Control subjects included 103 healthy blood donors (age range 18 to 78 years, mean age 54.6±15.2 years), whose blood samples were used to determine the reference values ​​correspon...

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Abstract

A method for determining whether a subject has had a stroke and, if so, the type of stroke which includes analyzing the subject's body fluid for at least four selected markers of stroke, namely myelin basic protein, S100 protein, neuronal specific enolase and a brain endothelial membrane protein such as thrombomodulin or a similar molecule. The data obtained from the analyses provide information as to the type of stroke, the onset of occurrence and the extent of brain damage and allow a physician to determine quickly the type of treatment required by the subject.

Description

Background of the invention [0001] The present invention relates to methods of diagnosing whether a subject has had a stroke, and differentiating the type of stroke in a stroke patient. More specifically, the method includes analyzing the body fluid of the subject for at least four selected stroke markers. The invention also describes diagnostic devices and kits for use in the methods. [0002] Stroke is very damaging to human health when considered for its lethality, and even more damaging when considered for its disabling nature. For example, stroke is the third leading cause of death among U.S. adults, behind ischemic heart disease and various types of cancer. For survivors, stroke is the leading cause of disability. The direct medical and unemployment costs of stroke run into the billions of dollars each year. Approximately 85% of strokes are ischemic (thrombotic and embolic) and the remainder are hemorrhagic. [0003] Stroke is an undertapped market for both therapeu...

Claims

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Application Information

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IPC IPC(8): C12Q1/00G01N33/68
CPCC12Q1/001Y10S435/975Y10S436/807Y10S435/973G01N33/6893Y10S435/969Y10S436/811G01N2800/2871Y10S435/97Y10S436/808G01N33/6896Y10S436/81
Inventor 乔治·杰科斯基
Owner SYN X PHARMA
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