Noninvasive method for measuring antimicrobial peptides from skin as an objective measure of natural defense against microorganisms
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An antimicrobial peptide, non-invasive technology, applied in measurement devices, biological tests, instruments, etc., can solve the problem of clear understanding of molecular events
Active Publication Date: 2018-06-12
PROCTER & GAMBLE CO
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New biomolecular capabilities have achieved a depth of understanding of pathophysiology that was previously achieved with traditional research approaches; however, a clear understanding of the molecular events leading to the key symptoms of this disorder has yet to emerge
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[0062] Basic procedure for AMP analysis
[0063] Subjects were evaluated by a qualified grader to determine the condition of their scalp. Dandruff subjects were evaluated by a qualified grader to identify their level of visible flakes. Subjects with healthy scalp without dandruff were evaluated at baseline to determine normalized levels of each biomarker. Subjects were identified by qualified raters in two separate clinical studies; Study #1 and Study #2. In Study #1, 60 dandruff-free subjects were assessed for baseline hBD2 levels. There were 119 dandruff patients treated with an anti-dandruff shampoo containing 1% ZPT, 115 dandruff patients treated with an anti-dandruff shampoo containing 1% selenium sulfide, and 60 dandruff subjects Treat with a non-anti-dandruff shampoo that does not contain anti-dandruff actives. Subjects were assessed for baseline levels of human beta defensin 2 (hBD2) and again after three weeks of product use.
[0064] In Study #2, 121 dandruff-...
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Abstract
The present invention discloses a non-invasive method for measuring skin health of a subject, the non-invasive method comprising collecting epithelial cells / skin cell samples from the subject; detecting in the epithelial cell samples / skin cell samples Content of one or more antimicrobial peptide biomarkers; diagnosis of whether a subject has a defense mechanism triggered by microbial invasion of the skin or whether the measurement system based on the content of one or more antimicrobial peptide biomarkers is in equilibrium with environmental homeostasis , wherein the one or more antimicrobial peptide biomarkers are selected from the group consisting of histone H2B type 1-M, histone H2A, histone H4, protein S100-A7, protein S100-A8, protein S100-A9, cathepsin G, Neutrophil defensin 3 (defensin, alpha 3) (HNP‑3), dermectin, ribonuclease 7 (RNase 7), human beta defensin 2 (nBD‑2) and beta defensin 103 (hBD ‑3) and those listed in Table 1, where the AMP family includes bactericidal permeability-increasing proteins (BPIs), defensins, histones, pore-forming toxins, S100 proteins, cytotoxins, serine protease S1, dioxygenases , transcription regulators, and mixtures thereof. The present invention also discloses a non-invasive method of assessing the efficacy of a product for skin health.
Description
technical field [0001] The present invention relates to a method for measuring the amount of one or more biomarkers associated with a defense mechanism initiated due to microbial attack on the skin, or whether the content measurement system based on one or more antimicrobial peptide biomarkers is compatible with the environment The homeostatic balance, and the correlation and correlation of the quantities of these biomarkers, as it directly correlates with the improvement of mammalian skin health. Background technique [0002] The scalp / skin is a remarkable organ system consisting of multiple specialized tissues that function as a first line of defense against environmental aggressors. While early research focused on the barrier function of the skin, it has become clear that this organ is dynamic: sensing and responding to even small changes in the environment, thereby helping to maintain homeostasis. Environmental influences such as solar radiation, pollution, or even the ...
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