Stabilized denatured lipoprotein and process for producing the same

A lipoprotein and stabilization technology, applied in the field of preparation of denatured lipoprotein, stabilized denatured lipoprotein and its preparation, can solve the problems of unsatisfactory storage stability and cumbersome operation of standard substances
CN1367794AInactive Publication Date: 2002-09-04KYOWA MEDEX CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
KYOWA MEDEX CO LTD
Publication Date
2002-09-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

Denatured lipoprotein excelling in stability of prolonged preservation (namely exhibiting only sparing liability to induce denaturation of lipoprotein) and used as a standard substance for the determination of denatured lipoprotein in blood or the determination of the physiological activity of the lipoprotein and a method for the production thereof are provided. The method for the production of the stabilized denatured lipoprotein comprises artificially denaturing lipoprotein, thereby obtaining denatured lipoprotein, freeze-drying the denatured lipoprotein or performing a process including at least one freezing operation on a solution containing denatured lipoprotein thereby denaturing the lipoprotein contained in the solution and obtaining denatured lipoprotein and further freeze-drying the denatured lipoprotein.
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Description

technical field

[0001] The invention relates to a stabilized denatured lipoprotein and a preparation method thereof. Specifically, the present invention relates to a denatured lipoprotein having excellent long-term storage stability obtained by denaturing the lipoprotein and then freeze-drying the denatured lipoprotein and a preparation method thereof.

[0002] The invention also relates to the preparation method of denatured lipoprotein. Specifically, the method for preparing denatured lipoproteins involved in the present invention is a method for denaturing lipoproteins by subjecting a solution containing lipoproteins to a step including at least one freezing step, and the present invention also relates to reproducing the denatured lipoproteins thus prepared. Denatured lipoprotein with excellent long-term storage stability obtained by freeze-drying and a preparation method thereof.

[0003] Denatured lipoproteins are known to be associated with diseases of the coronary art...

Claims

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