Composition of garcinolic acid compounds, its preparing process and medical composition using it as active component

A compound, the technology of gambogic acid, which is applied in the compound field of gambogic acid compounds, can solve the problems of unpublished experimental data and solubility, etc., and achieve high medicinal value, improved anti-tumor activity, and improved solubility

Inactive Publication Date: 2003-01-15
杭州爱大制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] People such as You Qidong of China Pharmaceutical University have proposed a compound (publication number CN1309125A, Chinese invention patent application on August 22, 2001) with arginine, lysine and gambogic acid compounds, thinking Can improve the water solubility of gambogic acid compounds, but failed to publish the experimental data and solubility

Method used

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  • Composition of garcinolic acid compounds, its preparing process and medical composition using it as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 10g (0.0157 moles) of total gambogic acid in a beaker, add an appropriate amount of distilled water, stir, slowly add 3g (0.0154 moles) of meglumine until it dissolves completely, filter, and freeze-dry the filtrate to obtain about 13g of solid, which is the total gambogic acid. Meglumine Xanthate Complex. Embodiment 2: the preparation of gambogic acid glucosamine complex

Embodiment 2

[0027] Take 10g (0.0159 moles) of gambogic acid in a beaker, add appropriate amount of ethanol to dissolve, then slowly add an appropriate amount of distilled water, under stirring, slowly add 3.1g (0.017 moles) of glucosamine, after the dissolution is complete, filter, and the filtrate Freeze-dry to obtain 14g gambogic acid glucosamine complex. Embodiment 3: the preparation of neogambogic acid meglumine complex

Embodiment 3

[0028] Take 10 g (0.0155 moles) of new gambogic acid in a beaker, add appropriate ethanol to dissolve, and slowly add 3.1 g (0.0159 moles) of meglumine under stirring, after the dissolution is complete, filter, and freeze-dry the filtrate to obtain 14 g of new gambogic Acid Meglumine Complex. Embodiment 4: Preparation of Gambogic Acid Glucosamine Compound Powder Injection

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Abstract

A composition for garcinolic acid compounds, the process for preparing it, an antineoplastic medical composition containing it, and the application of said composition and medical composition in preparing antineoplastic medicines are disclosed. Said composition features high water solubility and antineoplastic activity, and no influence to hemopoietic system and white cells.

Description

technical field [0001] The present invention relates to a novel complex of gambogic acid compounds, a preparation method thereof, a pharmaceutical composition containing the complex as an active ingredient, and their application in preparing drugs for treating tumors. Background technique [0002] Studies have shown that gambogic acid compounds have an inhibitory effect on tumor cells, but the solubility of gambogic acid compounds in water is extremely small, thus affecting their medicinal value. [0003] In recent years, academic circles have devoted themselves to improving the water solubility of gambogic acid compounds, looking for suitable compounds that can be combined with gambogic acid compounds to improve their solubility in water. [0004] People such as You Qidong of China Pharmaceutical University have proposed a compound (publication number CN1309125A, Chinese invention patent application on August 22, 2001) with arginine, lysine and gambogi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00C07D493/12
Inventor 金彪董辉乔林沈国伟
Owner 杭州爱大制药有限公司
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