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Polymeric micelle compsns.

A technology of composition and micelles, which is applied in the direction of drug combination, microcapsules, capsule delivery, etc., can solve the problem that the formation process of polymeric micelles is not determined

Inactive Publication Date: 2003-10-08
制药实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this study, PLLA macromonomers were copolymerized with VP, but the formation process of aggregated micelles has not been determined

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0022] The present invention provides a colloidal composition, which is composed of polymeric micelles, wherein the polymeric micelles can be used to deliver therapeutic agents with poor water solubility and / or specific affinity with a hydrophilic shell. The polymeric micelles are characterized by a core-shell structure in which a hydrophobic core is surrounded by a hydrophilic shell. The hydrophilic shell comprises a hydrophilic polymer or copolymer.

[0023] The hydrophilic polymer of the present invention is a polymer or copolymer of poly(N-vinyl-2-pyrrolidone) (PVP).

[0024]The hydrophobic part constitutes the core of the micelles. The hydrophobic portion may be selected from polyesters such as poly(glycolic acid), poly(lactic acid), poly(D-lactic acid), poly(D,L-lactic acid), lactide / glycolide copolymers, polycaprolactone and its derivatives; polyorthoesters and their derivatives; polyanhydrides and their derivatives; pseudo-poly(amino acids) from tyrosine and their de...

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Abstract

Novel polymeric micelles which are used to deliver therapeutic agents, including anti tumor drugs.

Description

1. Field of invention [0001] The present invention relates to compositions comprising polymeric micelles for the delivery of therapeutic agents, including but not limited to antineoplastic drugs. 2. Background of the invention [0002] A major obstacle associated with the use of chemotherapeutic agents is the lack of selectivity for cancer cells. This lack of selectivity has been linked to deleterious side effects associated with the use of these agents, since they can be delivered to both abnormal and normal cells. In the process of treating various diseases besides cancer, the lack of selectivity of drugs for target cells is also a problem. Most research efforts have focused on developing drug carriers that can selectively deliver drugs to target cells. For example, in order to improve the delivery selectivity of drugs with low therapeutic index, a variety of drug carriers, such as liposomes, microparticles, nanoconjugates, and drug-polymer conjugates...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/107A61K9/48A61K9/51A61K31/17A61K31/337A61K31/407A61K31/409A61K31/513A61K31/519A61K31/704A61K47/34A61K48/00A61P35/00
CPCY10S977/906A61K9/1075A61P31/00A61P35/00A61P37/00A61P39/00A61K9/127
Inventor J·C·勒罗克斯A·S·贝纳梅德
Owner 制药实验室有限公司