Agents for measuring pyrimidine metabolizability
A technology of metabolic ability and pyrimidine, which is applied in the field of preparations, can solve problems such as unexplained, decreased DPD activity, and difficulty in evaluating whether DPD activity exists or not.
Inactive Publication Date: 2004-05-19
OTSUKA PHARM CO LTD
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AI-Extracted Technical Summary
Problems solved by technology
The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.
Compounds screening/testingDispersion delivery +2
DrugPyrimidine metabolism +9
- Experimental program(5)
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