Use of central China fruit of Chinese magnoliavine ketone in preparing medicine for food for preventing and treating Alzheimer's disease

A technology of Alzheimer's disease and schisandra, applied in the field of medicine

Inactive Publication Date: 2005-01-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it has a preventive effect on AD has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1. Cell experiment

[0009] (1) Animals Newborn SD rats within 24 hours were provided by the Experimental Animal Center of Second Military Medical University.

[0010] (2) Drugs and reagents DMEM medium (Gibco company), Neuro-basal+B27 (Gibco company), fetal bovine serum (Gibco company), horse serum (Gibco company), poly-L-lysine (Sigma company ), Cytarabine (Pharmacia), Aβ 25-35 (Sigma company), Huazhong schisandrone (purity > 98%) was provided by Professor Chen Haisheng, Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University (see Li LN for details, Xue H. Schisandrone, a new 4-aryltetralonelignan from Schisandra sphenanthera. Planta medica.1985; (3): 217.), reactive oxygen species assay kit (Nanjing Jiancheng Institute of Bioengineering), total RNA extraction reagent Trizol (Gibco company), One Step RNAPCRKit (TaKaRa company), agarose (Promega company).

[0011] (3) Preparation of neuron cells and microglial cells ...

Embodiment 2

[0065] Embodiment 2. Animal experiments

[0066] (1) Animals and feeding Male SD rats, aged 8-12 weeks, weighing 250-300 g, were provided by the Experimental Animal Center of Second Military Medical University. Raising under standard environment: temperature (23±0.5)°C, humidity (50±0.5)%, natural light, free access to food and water.

[0067] (2) Solution preparation

[0068] 1. Preparation of Aβ solution for intracerebroventricular injection 25-35 Dissolve in sterile normal saline to make the Aβ concentration 10mmol / L, incubate in a 37°C incubator for 3 days, and then age for later use.

[0069] 2. Preparation of Huazhong Schisandrin solution for gavage Dissolve Huazhong Schisandrin in corn oil to a concentration of 1 mmol / L for later use.

[0070] (3) Experimental method SD rats were randomly divided into 3 groups: blank control group, Aβ injury group and Schizandrone intervention group.

[0071] 1. Rats in the blank control group were given corn oil by gavage for 7 day...

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Abstract

An appliation of schisandrone is preparing the medicine or food for preventing and treating Alzheimer's disease (AD) is disclosed as it can decrease the generation of active oxygen in neunon cell and the transcription level of IL-1 beta in microglia and iNOS, and improve the damaged memory.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of schisandrin in the preparation of medicine or food for preventing and treating Alzheimer's disease (Alzheimer's Disease, AD). Background technique [0002] AD is an senile central nervous system degenerative disease characterized by memory loss, cognitive impairment, and personality changes. With the aging of the global population, the prevention and treatment of AD has become a prominent medical and social problem that needs to be solved urgently. However, because the etiology of AD is not completely clear, there is no effective prevention and treatment drug so far. [0003] Senile plaques formed by abnormal deposition of β-amyloid protein (Beta-Amyloid Protein, Aβ) is a typical pathological feature of AD. Significant neurodegeneration and activation of glial cells around plaques suggest that Aβ may be responsible for neuronal loss and infla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P25/28
Inventor 拓西平陈海生贾丽艳周俊朱嘉琦
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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