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A technology of Zhibai Dihuang and its preparation process is applied in the field of production technology of Chinese patent medicines, which can solve the problems of difficulty in proposing active ingredients, slow dissolution and dispersing of concentrated pills, low bioavailability, etc. small amount of effect

Inactive Publication Date: 2005-01-19
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But making a general survey of the technology and preparations of the above-mentioned products, there are deficiencies: (1) Zhibai Dihuang Tablets (included in the fifth volume of Chinese medicine prescription preparations of the Ministry of Health of the People's Republic of China) its technology is: Chinese yam, dogwood, zebra Xie pulverized into fine powder; Cortex Moutan crushed into fine powder; the other four flavors such as Anemarrhena anemarrhena were extracted with water, concentrated into a thick paste, mixed with the above-mentioned three flavors fine powder such as yam, dried, pulverized, and then mixed with the fine powder of Cortex Moutan, Granulated with auxiliary materials, compressed into tablets, coated with sugar
The prescription amount of this concentrated pill is reduced by about one-third on the basis of the pill, but 8 pills are still required to be taken each time. Part of the cornus officinalis and Moutan cortex in the prescription are extracted by percolation with 70% ethanol, and then concentrated and dried In the process, the volatile components in Moutan cortex are easy to lose, but it is difficult to extract active ingredients such as polysaccharides in Cornus officinalis that have obvious immune-enhancing and anti-aging activities, and Cortex Phellodendron is fried with other medicinal materials, and the alkaline components in Cortex Phellodendri are easily mixed with other medicinal materials. Some acidic components in the medicinal materials react, resulting in the loss of active ingredients. At the same time, the concentrated pills also have the disadvantages of slow dissolution and low bioavailability
[0004] To sum up, although there are many dosage forms of Zhibai Dihuang at present, it can not only fully retain the active ingredients of the prescription Chinese medicinal materials to ensure the curative effect, but also achieve exquisite preparation and small dosage, which can fully reflect the modernization of traditional Chinese medicine preparations. can say no

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Preparation of Zhibai Dihuang Capsules

[0036]Separately select the eight herbs, remove impurities, and pass the test for later use; crush the eight herbs into coarse powder for later use; take Moutan cortex and distill it with water to extract paeonol, and dissolve it with an appropriate amount of absolute ethanol for later use; the distilled aqueous solution is super Filter and set aside; Cornus officinalis and Anemarrhena are extracted twice with 70% ethanol, the extracts are combined, ultrafiltered, and the filtrate recovers ethanol for later use; Poria cocos is soaked in water twice, the extracts are combined, ultrafiltered, and the filtrate is set aside; 2 hours for the first time, 1 hour for the second and third times, combine the decoction, ultrafiltration, and concentrate the filtrate to an appropriate amount for later use; decoct Rehmannia glutinosa, yam, and Alisma 3 times with water, for 2 hours each for the first and second time, Three times for...

Embodiment 2

[0037] Example 2: Preparation of Zhibai Dihuang Capsules

[0038] Separately select the eight herbs, remove impurities, and pass the test for later use; crush the eight herbs into coarse powder for later use; take Moutan bark and add water to distill, extract paeonol, and make -cyclodextrin inclusion compound for later use; after distillation The aqueous solution ultrafiltration is used for standby; the dregs, Rehmannia glutinosa, Alisma, Cornus officinalis, and Anemarrhena are extracted twice with 90% ethanol, the extracts are combined, ultrafiltered, and the ethanol is recovered from the filtrate for later use; Poria cocos is soaked twice in water, the extracts are combined, and the ultrafiltration is performed. Filtrate, and set aside the filtrate; decoct Phellodendron 3 times with water, 2 hours for the first time, 1 hour each for the second and third times, combine the decoction, ultrafiltration, and concentrate the filtrate to an appropriate amount for later use; Each ti...

Embodiment 3

[0039] Embodiment 3: Preparation of Zhibai Dihuang Tablets

[0040] The eight medicinal herbs were cleaned separately to remove impurities and passed the inspection for later use; the Phellodendron cortex was crushed into fine powder for later use; the remaining seven medicinal herbs were respectively crushed into coarse powder for later use; the cortex of Moutan was added to water and vacuum distilled to extract paeonol, and an appropriate amount of anhydrous Dissolve in ethanol for later use; filter the distilled aqueous solution for later use; extract twice with 90% ethanol for medicinal residues, Cornus officinalis and Anemarrhena, combine the extracts, filter, and recover the ethanol from the filtrate for later use; soak Poria cocos in warm water twice, and filter the leaching solution. The filtrate is ready for use; Rehmannia glutinosa, yam, and Alisma are decocted with water for 3 times, the first and second times are 2 hours each, and the third time is 1 hour. Add the ...

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PUM

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Abstract

The invention discloses a Novel 'ZhiBai Dihuang' formulation and its preparation, characterized by the modification to the preparing process by using the novel medicament preparing technologies, which achieves the beneficial effects of good curative effect, small amount of administration and easiness in carrying. The formulation can be used for treating asthenic fire, hectic fever, perspire during sleep, dry mouth, acoasm and scanty red urine.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparation technology, in particular to the preparation technology of Zhibai Dihuangxin and its preparation. Background technique [0002] The prescription of Zhibai Dihuang Wan came out of the "Yi Zong Jin Jian" in the Qing Dynasty. It is composed of Liuwei Dihuang Wan plus Anemarrhena and Cortex Phellodendri. It is a famous prescription for nourishing yin and reducing fire. It has the function of nourishing yin and reducing fire. Hot night sweats, dry mouth and sore throat, tinnitus, nocturnal emission, short red urine and other symptoms, the curative effect is remarkable. The process of the pill is that the eight medicinal materials in the prescription are crushed into fine powder, and an appropriate amount of refined honey / honey water is added to make honeyed pills / water honeyed pills. Because all the raw powders of the traditional Chinese medicines in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61P1/14A61P11/04A61P29/00
Inventor 毛友昌毛小敏
Owner 毛友昌
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