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Preparation method and quality control method of Yulan Jiangtang capsule extract

A quality control method and Yulan hypoglycemic technology, applied in the preparation of Yulan Jiangtang capsule extract, the field of quality control of Yulan Jiangtang capsule extract, can solve the problem of insignificant effect, increased dosage, and no quality identification standard and other problems to achieve the effect of controlling product quality and improving product quality

Inactive Publication Date: 2018-10-09
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Diabetes is a frequently-occurring disease that seriously endangers human health. At present, there are nearly 20 million patients in China, and there is an increasing trend year by year. The mortality rate is second only to malignant tumors and cardiovascular diseases, and it is the third largest disease that endangers human life. Diabetes will not heal for life , extensive and serious complications, due to the relative or absolute lack of insulin in the blood stream, causing sugar, fat, protein metabolism disorders, resulting in high blood pressure, hyperlipidemia, and increased blood viscosity, and extensive microvascular lesions throughout the body in the middle and late stages, of which 70- 80% of patients die of cardiovascular disease, renal failure and cerebrovascular accident are common causes of death in middle-aged and elderly diabetic patients; at present, the drug treatment of this disease at home and abroad is adopted: 1. Biguanide drug treatment, its curative effect is low 1. Large side effects, long-term use can cause hyperlactic acidemia; 2. Long-term use of iodourea drugs can damage the liver, kidney and blood cells, and cross allergies with sulfa drugs, resulting in secondary failure in the later stage; 3. Insulin therapy, long-term use is easy Produce antibodies, reduce biological activity, increase dosage, produce hyperinsulinemia, and promote the occurrence and development of microvascular lesions
Although our country has some Chinese patent medicines for the treatment of this disease in recent years, because the effect is not obvious, patients still have to rely on some western medicines, so there are still the above problems
The Chinese patent with the publication number CN1415323A discloses that the Chinese patent medicine for treating diabetes has obvious curative effect on diabetes, but it does not disclose the preparation method of Yulan Jiangtang Capsules, and there is no quality appraisal standard

Method used

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  • Preparation method and quality control method of Yulan Jiangtang capsule extract
  • Preparation method and quality control method of Yulan Jiangtang capsule extract
  • Preparation method and quality control method of Yulan Jiangtang capsule extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the preparation method of Yulan Jiangtang capsule extract

[0023] The preparation method of Yulan Jiangtang Capsule Extract comprises the following steps: get 620g of Scutellaria baicalensis, 285g of mulberry leaves, 260g of arctium burdock, 180g of blue ginseng, 170g of Scutellaria barbata, 120g of false longevity bamboo root, 93g of Qingzhizi, 30g mulberry leaves are crushed into fine powder (through 80 mesh sieve), the remaining mulberry leaves and other six flavors are decocted in boiling water twice, the first time is 2 hours, the second time is 1.5 hours, the decoctions are combined, filtered, and the filtrate is concentrated to relative The clear paste with a density of 1.17-1.20 (80°C) is ready, and the prepared clear paste is brown.

[0024] The conversion rate of baicalin can be improved by adding boiling water and decocting in the preparation process.

Embodiment 2

[0025] Embodiment 2, the quality control method of blue Jiangtang capsule extract

[0026]The quality control method of Lanjiangtang capsule extract, including baicalin identification, mulberry leaf identification, arctiin identification and baicalin content detection;

[0027] Wherein the identification of baicalin is as follows: take Yulan Jiangtang Capsule extract 1ml (respectively take 5 batch numbers for testing: T20130601-YJ, T20130602-YJ, T20130603-YJ, T20130604-YJ, T20130605-YJ), add methanol 20ml, Sonicate for 15 minutes, filter, evaporate the filtrate to dryness, add methanol 3ml to dissolve the residue, and use it as the test solution. Take another baicalin reference substance (batch number: 110715-201016, source: China Institute for the Control of Pharmaceutical and Biological Products), add methanol to make a solution containing 1mg per 1ml, and use it as the reference substance solution. According to the thin-layer chromatography (Appendix VIB of "Chinese Pharma...

Embodiment 3

[0032] (1) Selection of sample processing solvent

[0033] Accurately weigh 35.98mg of baicalin reference substance, put in a 50ml volumetric flask, add methanol to dissolve and dilute to the mark, and obtain a stock solution containing 0.6764mg per 1ml. Precisely measure 5ml of the stock solution, put it in a 50ml volumetric flask, add methanol to dissolve and dilute to the mark, and shake well to obtain a reference substance solution containing 0.06764mg per 1ml. Referring to the content determination method of the finished Yulan Jiangtang Capsules, take 10 parts of the test product (batch number: T20130607-FJ), each 1.5g, accurately weighed, put in a stoppered triangle bottle, add 25ml of methanol to No. 1 and No. 2, Add 25ml of ethanol to No. 3 and No. 4 precision, add 25ml of 75% ethanol to No. 5 and No. 6 precision, add 25ml of 70% ethanol to No. 7 and No. 8 precision, add 25ml of 65% ethanol to No. 9 and No. 10 precision, weigh the weight, and ultrasonic for 30 minutes....

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Abstract

The invention relates to a preparation method and quality control method of Yulan Jiangtang capsule extract. The preparation method comprises the following steps: taking radix scutellariae, folium mori, fructus arctii, radix wahlenbergiae marginatae, herba scutellariae barbatae, disporopsis longifolia root and semen celosiae; crushing part of the folium mori into fine powder; adding water into theresidual folium mori and the residual six medicines and decocting for two times; combining decoction and filtering; concentrating filtrate to obtain extract with the relative density of 1.17 to 1.20(at 80 DEG C), so as to obtain a product. According to the method provided by the invention, effective components can be sufficiently kept; the invention further discloses the quality control method of the Yulan Jiangtang capsule extract, and the quality of the product can be controlled better.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of Yulan Jiangtang capsule extract, and also relates to a quality control method of Yulan Jiangtang capsule extract. Background technique [0002] Diabetes is a frequently-occurring disease that seriously endangers human health. At present, there are nearly 20 million patients in China, and there is an increasing trend year by year. The mortality rate is second only to malignant tumors and cardiovascular diseases, and it is the third largest disease that endangers human life. Diabetes will not heal for life , extensive and serious complications, due to the relative or absolute lack of insulin in the blood stream, causing sugar, fat, protein metabolism disorders, resulting in high blood pressure, hyperlipidemia, and increased blood viscosity, and extensive microvascular lesions throughout the body in the middle and late stages, of which 70...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/48A61P3/10G01N30/90
CPCA61K36/539A61K9/48A61K36/21A61K36/28A61K36/34A61K36/605A61K36/896A61K2236/331A61K2236/39A61K2236/51A61P3/10G01N30/90A61K2300/00
Inventor 孙小鹦廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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