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Application of cnidium fruit element in the preparing process of medicine for preventing and treating Sexual dysfunction

A technology of osthole and sexual function, which is applied in drug delivery, drug combination, diseases, etc., and can solve problems such as unseen sexual dysfunction

Inactive Publication Date: 2005-04-13
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report about treating sexual dysfunction with osthole at home and abroad.

Method used

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  • Application of cnidium fruit element in the preparing process of medicine for preventing and treating Sexual dysfunction
  • Application of cnidium fruit element in the preparing process of medicine for preventing and treating Sexual dysfunction
  • Application of cnidium fruit element in the preparing process of medicine for preventing and treating Sexual dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] According to the rules of acute toxicity test, the LD50 of mice was not detected by oral administration of osthole once, so its maximum tolerated dose (MTD) was changed. MTD test results showed that: 20 mice had no obvious toxic reaction after administration, and no death occurred within two weeks. Therefore, the maximum tolerated dose of osthole in mice once administered orally is greater than 5.0 g / kg, which belongs to "actually non-toxic".

[0037] 2. Drug efficacy and pharmacological effect experiment:

Embodiment 2

[0038] Example 2 Effect of osthole on sexual behavior of male mice

[0039] Kunming male mice (30-34g) and alloestrogenized female mice (30-34g after subcutaneous injection of estradiol benzoate 20 μg / mouse, used after 48 hours) were housed together for 4 days (1 male + 1 female) ), allowing male mice to gain sexual experience. On the 5th day, the female mice were taken out, and the male mice were allowed to rest for 3 days. Male rats were randomly divided into three groups: (1) control group, fed with corresponding solvent; (2) 50 mg / kg dose group; (3) 100 mg / kg dose group. Seven rats in each group were administered orally, once a day, for 10 consecutive days. The sexual behavior of male mice was detected 2hr after the last administration. Tested male mice were placed in a container (diameter 24cm, height 24cm) for 5 minutes to adapt to, put 2 estrogenized female mice, and observe the male mouse riding within 15 minutes (including the riding latency period) through a close...

Embodiment 3

[0059] Example 3 Effect of osthole and positive control drug Jinkuishenqi pill on sexual behavior of male mice

[0060] Kunming male mice (30-34g) and alloestrogenized female mice (30-34g after subcutaneous injection of estradiol benzoate 20 μg / mouse, used after 48 hours) were housed together for 4 days (1 male + 1 female) ), allowing male mice to gain sexual experience. On the 5th day, the female mice were taken out, and the male mice were allowed to rest for 3 days. Male rats were randomly divided into three groups: (1) control group, fed with corresponding solvent; (2) Jinkuishenqi pill positive control group, dose: 1.8g / Kg, (10×human dose); (3) osthole group , dose: 100mg / kg. Seven rats in each group were administered orally, once a day, for 10 consecutive days. The sexual behavior of male mice was detected 2hr after the last administration. Put the male mice in a container (diameter 24cm, height 24cm) to adapt for 5 minutes, put 2 estrogenized female mice, and observe...

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PUM

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Abstract

The present invention discloses the application of cnidiadin in preparing medicine for preventing and treating sexual dysfunction.

Description

technical field [0001] The invention relates to the application of osthole in the preparation of medicines for preventing and treating sexual dysfunction. Background technique [0002] Male sexual dysfunction is a common disease with a high incidence rate and a wide range of distribution, and is affected by many factors such as age, environment, and psychology. In modern society, people's pace of life is accelerated, competition is fierce, and mental pressure is high, which greatly increases the incidence of male sexual dysfunction. At present, about 100 million men in the world have different degrees of sexual dysfunction. More than 50% of men over the age of 40 have different degrees of sexual dysfunction. There are 20-30 million men in the United States, and 30% of men in Japan have different degrees of sexual dysfunction; An epidemiological survey of middle-aged and elderly men found that 73.1% of them suffer from sexual dysfunction, and the incidence rate increases wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/366A61P15/08
Inventor 费仁仁陈若云朱海波张岭
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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