Composition for treating contact lenses
A composition and technology for contact lenses, which are applied in lens cleaning compositions, detergent compositions, organic cleaning compositions, etc., can solve problems such as no suggestion that tromethamine can stabilize proteins and prevent denaturation.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0034] Prepare a series of 10 mL test solutions listed in Table 1 below. Each solution contained saline and 20 mM of the buffers given in Table 1 below. 1 mg / ml egg lysozyme was added to each test solution, along with a phosphate buffered saline (PBS) control. The test solution was slowly mixed with a stir bar until the lysozyme was incorporated into the solution. 5 ml of each test solution containing lysozyme was retained as an unheated control. The remaining 5 ml of each lysozyme-containing test solution was placed in a glass vial, sealed with a silicone stopper and incubated at 80°C for 1 hour in a shaking water bath at 40 revolutions per minute (rpm). In the case of stabilization, these heating conditions were sufficient to denature lysozyme.
[0035] Vials were allowed to cool to room temperature prior to testing. A 0.00025 g / ml suspension of M.luteus was prepared in PBS from freeze-dried pools. During the test, the suspension was continuously mixed on a stirring tab...
Embodiment 2-5
[0074] Representative compositions of the present invention are given in Table 2 below. The compositions listed in Table 2 as Examples 2-5 were prepared according to the following method. Add non-polymer components such as tromethamine, tromethamine hydrochloride, sodium chloride, EDTA, Dequest, sodium borate and boric acid into hot water (about 50°C) sequentially, the amount of hot water is the final batch About 70-85% of the volume. This addition is done with constant agitation and each component is allowed to dissolve or disperse before adding the next component. Subsequently, Tetronic 1107 and PHMB were added with stirring to ensure adequate dispersion of the polymer. The resulting solution was mixed until complete dissolution was achieved. Cool the batch to room temperature with stirring. Adjust pH to about 7.1-7.5 by adding 1 N NaOH or 1 N HCl, then bring to final volume by adding water (20-30° C.) and mix for at least 15 minutes.
[0075] Composition (w / w%...
Embodiment 2
[0082] Example 2 Lysozyme / no heating 0.771 0.087 0.056 88.67 92.78
[0083] Lysozyme + heating 1.019 0.770 0.501 24.46 50.85
[0084] No lysozyme 1.006 1.001 1.002 0.50 0.40
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More