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Culture of Chansi mould strains and extraction and use of anagentic compound therefrom

A technology of Paecilomyces cicadae strains and Paecilomyces cicadae, applied to medical preparations containing active ingredients, fungi, drug combinations, etc.

Active Publication Date: 2005-05-11
ZHEJIANG CHENGYI PAHRMACEUTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the analgesic active substance of Paecilomyces cicadae and its preparation method and utilization have not been reported yet. Therefore, the analgesic chemical components of Paecilomyces cicadae and their extraction methods are clarified, and then developed into a new type of safe analgesic Pain drugs have important social and economic benefits

Method used

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  • Culture of Chansi mould strains and extraction and use of anagentic compound therefrom
  • Culture of Chansi mould strains and extraction and use of anagentic compound therefrom
  • Culture of Chansi mould strains and extraction and use of anagentic compound therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Embodiment 1: (solid culture fermentation method " 1 ")

[0121] Take the APC-20 strain stored in the refrigerator at 4°C and transplant it to the slant culture medium (Note 1) for 7 days, activate it for use; each 500ml triangular bottle contains 200ml of the first-grade seed medium (Note 2), and insert the slant strain 3 rings of spore powder, placed in a DHZ-C oscillator at 25°C, 120r / min, and cultivated for 4 days as first-grade seeds; put 7.5L of secondary medium in a 10L fermenter (Note 3), and sterilize at 121°C for 30 minutes Cool to 24°C, insert first-grade seeds according to 10% inoculation amount, at 24°C, tank pressure is about 0.04Mpa, air flow is about 0.75m 3 / h, fermented for 48 hours as secondary seeds. After mixing the solid medium (Note 4) and water at a ratio of 1:2, one method can be directly loaded into the culture container, preferably about 2 / 5 of the capacity, placed in a high-pressure steam boiler, heated at 121°C , after 0.11Mpa sterilization...

Embodiment 2

[0126] Embodiment 2: (solid culture fermentation method " 2 ")

[0127] The solid fermentation medium of the present embodiment is bran: corn: bran in a ratio of 2: 1: 1; the solid medium dry material and water are mixed in a ratio of 1: 2.9 weight components;

[0128] The inoculation amount of secondary strains for closed container culture is 3%; the inoculum amount of secondary strains for open culture in curved disc is 10%;

[0129] The culture medium and other processes and steps of this embodiment are the same as those in Example 1.

Embodiment 3

[0130] Embodiment 3: (solid culture fermentation method " 3 ")

[0131] Use wheat grains as the solid medium, first soak the grains in water overnight, steam them (until the grains crack), and put them into a container or a bent plate to occupy one-third of the volume; the secondary or tertiary bacteria cultured in closed containers The seed inoculum amount is 3%; the strain inoculum amount of the open culture of the curved disc is 10%; the rest of the culture process and steps are the same as in Example 1.

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Abstract

An artificial culture method of new balm cricket Penicillium notatum and extraction and application of delivery pains compounds are disclosed. This invention involves declutching and breeding quality new balm cricket Penicillium notatum APC-20 from nature, researching production of the strain, further, defining method of extracting delivery pains compounds to be medicine. The compound is N6-(2- hydroxyethyl) adenosine. Molecular weight is 311.297. Molecular formula is C12H17N5O5. Delivery pains ratio is 99%by the method of mouse test. Principle of delivery pains is particular and cannot induce addiction.

Description

technical field [0001] The invention relates to the technical field of Cordyceps fungus fermentation, extraction and utilization of effective parts, in particular to artificial solid and / or liquid fermentation of a new strain of Paecilomyces cicadae APC-20, from which compounds with analgesic activity are extracted and prepared into Pain medication. Background technique [0002] Cicadae has been a precious Chinese medicinal material with high medicinal value since ancient times. It is a complex parasitic on cicada nymphs by Paecilomyces cicadae (genus Cordyceps). In the past, people mainly collected rare natural cicadae for various health care products or as compatible medicinal materials and nourishing medicinal diet. But the natural cicadae has become less and less, and the output is low, and it can only be harvested once a year, and the quality of the product is uneven due to the impact of the environment. The existing Paecilomyces cicadae in n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P43/00C07K1/14C12N1/14C12P1/02C12P21/02
Inventor 柴一秋韦忠民陈祝安厉晓腊刘又高王根锷
Owner ZHEJIANG CHENGYI PAHRMACEUTICAL
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