Mitiglinide/metformin hydrochloride oral compound antihypelipidemic preparation and preparation method thereof

A metformin hydrochloride and hypoglycemic technology, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, metabolic diseases, etc., can solve problems such as excessive dieting and physical harm, and achieve the goal of increasing utilization, inhibiting decomposition, and reducing insulin resistance Effect

Inactive Publication Date: 2005-06-22
海南国栋药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients who only rely on diet or exercise to control blood sugar levels, faced with all kinds of delicious temptations, they often dare not eat or go on excessive diets because of fear of blood sugar rise, which will cause different degrees of harm to the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Tablet: The weight ratio of mitiglinide to metformin hydrochloride is 5 mg:250, 5 mg:500 mg, 22 mg:250 mg, and 22 mg:500 mg. After mixing with an appropriate amount of pharmaceutical excipients, granulate, dry, granulate, blend, compress into tablets (coating), and pack.

Embodiment 2

[0020] Embodiment 2: Capsules: the weight ratio of mitiglinide to metformin hydrochloride is 5mg: 250mg, 5mg: 500mg, 22mg: 250mg and 22mg: 500mg, after mixing with appropriate amount of pharmaceutical excipients, granulate, dry and granulate , Blending, tableting, filling, packaging.

Embodiment 3

[0021] Embodiment 3: Granules: the weight ratio of mitiglinide to metformin hydrochloride is 5mg: 250mg, 5mg: 500mg, 22mg: 250mg and 22mg: 500mg, after mixing with appropriate amount of pharmaceutical excipients, granulate, dry and granulate , Grading or coating sub-dose packaging.

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PUM

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Abstract

The invention relates to a mitiglinide / metformin hydrochloride oral compound antihypelipidemic preparation and its preparation process, wherein the effective components in mitiglinide / metformin hydrochloride can be utilized collectively, the weight ratio of the mitiglinide / metformin hydrochloride in the oral compound preparation is 3:10-1:500 is 5mg : 250mg, 5mg : 500mg, 22mg : 250mg, 22mg : 500mg, and right amount of medicinal adjuvant. The invention solves the problem of unstable curative effect for the common blood sugar lowering preparation.

Description

【Technical field】 [0001] The invention relates to a group of new hypoglycemic preparations, that is, Mitiglinide / Metformin HCI oral compound preparation and a preparation method thereof. 【Background technique】 [0002] Diabetes is a common and frequently-occurring disease, and it is also a worldwide disease. According to the statistics of the World Health Organization, there were about 30 million diabetics in the world in 1985, which increased to 135 million in 1997 and 143 million in 1999. , it is estimated that in 2010 will reach 240 million. According to my country's official report, there were about 40 million people with diabetes in 2002, and by 2010, the number will increase by 60 million. This is a huge group of diseases, and its serious complications have a huge impact on people's health and a huge economic burden on the government and society. How to control the occurrence and development of diabetes, and control the occurrence of complications, the most important...

Claims

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Application Information

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IPC IPC(8): A61K31/403A61P3/10
Inventor 梁国栋杨东云郭海琳杨平郑松
Owner 海南国栋药物研究所有限公司
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