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Sustained release medicine for artificially inducing sex reversal of grouper and its preparation method

A slow-release drug, grouper-specific technology, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as insufficient mature male fish, avoid polluting water bodies and fish bodies, induce The effect of sexual reversal is stable and reliable, and the effect is highly targeted

Inactive Publication Date: 2005-06-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a slow-release drug that can be embedded in the body of female grouper, has a stable and reliable inductive reversal effect, and conforms to the principle of "minimum interference", so as to solve the problem of insufficient number of mature male fish in the process of artificial reproduction. To further meet the demand for male fish in large-scale artificial breeding of grouper

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] 1. The composition of sustained-release medicine of the present invention

[0023] The composition and proportioning of sustained-release medicine of the present invention are as follows:

[0024] 15 grams of Fadrozole, 75 grams of silastic brand MDX4-4210 medical grade elastomer base (silastic MDX4-4210 medical grade elastomer base), 10 grams of silastic brand MDX4-4210 curing agent .

[0025] 2. The preparation method of slow-release medicine of the present invention

[0026] (1) fully mix the above-mentioned aromatase inhibitor and medical unpolymerized silicone rubber, then add coagulant, and fully mix again;

[0027] (2) Apply vegetable oil on the special formwork with small grooves, press the mixture evenly into the small grooves of the formwork with special tools, and dry under aseptic conditions below 40°C for 24 hours;

[0028] (3) Take out the dried and formed mixture strip with tweezers, and put it in a 4°C refrigerator for storage for later use. Calculat...

example 2

[0032] 1. The composition of sustained-release medicine of the present invention

[0033] The composition and proportioning of sustained-release medicine of the present invention are as follows:

[0034] Vorozole (Vorozole) 1.5 grams, silastic brand MDX4-4210 type medical synthetic rubber base (silastic MDX4-4210 medical grade elastomer base) 90 grams, silastic brand MDX4-4210 type curing agent (silastic MDX4-4210 curing agent) 8.5 grams .

[0035] 2. The preparation method of slow-release medicine of the present invention

[0036] The difference from Example 1 is that the mixture is naturally dried and shaped under aseptic conditions in step (2).

[0037] 3. The use method of sustained-release medicine of the present invention

[0038] The difference from Example 1 is that the dose of aromatase inhibition of 1 mg per kilogram of grouper body weight is implanted, and the drug strip is implanted into the abdomen of female grouper. After operation, 100% of the fish survived....

example 3

[0040] 1. Invention of the composition of sustained-release drugs

[0041] The composition and proportioning of sustained-release medicine of the present invention are as follows:

[0042] Letrozole (Letrozole) 10 grams, silastic brand MDX4-4210 type medical synthetic rubber matrix (silastic MDX4-4210 medical grade elastomer base) 81 grams, silastic brand MDX4-4210 type curing agent (silastic MDX4-4210 curing agent) 9 grams . The above-mentioned letrozole (Letrozole) can also be replaced by formestane (Formestane) or anastrozole (Anastrozole).

[0043] 2. The preparation method of sustained-release medicine of the present invention

[0044] The difference from Example 1 is that the mixture is naturally dried and shaped under aseptic conditions in step (2).

[0045] 3., the use method of sustained-release medicine of the present invention

[0046] The difference from Example 1 is that the dose of aromatase inhibition of 5 mg per kilogram of grouper body weight is implanted,...

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PUM

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Abstract

The invention provides a sustained release medicine for artificially inducing sex reversal of grouper and its preparation method, wherein the medicine comprises aromatase inhibitor 1.5-15%, synthetic rubber base material for medical purpose 75-90%, hardening agent 8.5-10%, the process for preparing the medicament comprises mixing homogeneously, dry forming, and refrigerated preservation.

Description

technical field [0001] The invention relates to a medicine for controlling the sex of fish, in particular to a slow-release medicine for artificially inducing sex reversal of grouper, and also relates to a preparation method of the slow-release medicine. Background technique [0002] Grouper is one of the famous and precious marine economic fish in my country, which belongs to Perciformes (Perciformes), Serranidae (Serranidae), grouper subfamily (Epinephelinae), grouper (Epinephelus), and is a hermaphrodite fish. In the process of individual development, it is female first and then male, and there is a phenomenon of sex reversal. More than 400 species of grouper have been reported in the world, and 45 species have been recorded along the coast of mainland my country. The grouper has delicious meat, rich nutrition and high economic value. However, the large-scale artificial breeding technology of grouper fry is not yet mature. At present, the cultured fry are still mainly so...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61K45/08A61P15/00
Inventor 刘晓春李广丽林浩然
Owner SUN YAT SEN UNIV
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