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Topical composition containing at least one vitamin D or one vitamin D analogue and at least one corticosteroid

A corticosteroid, composition technology, applied in the field of topical composition, can solve the problem of non-compliance with the treatment system and the like

Inactive Publication Date: 2005-06-29
LEO PHARMA AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They reported that poor compliance with treatment recommendations in chronic conditions such as psoriasis represents a major challenge for healthcare: 39% of participants reported that they did not follow the recommended treatment regime

Method used

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  • Topical composition containing at least one vitamin D or one vitamin D analogue and at least one corticosteroid

Examples

Experimental program
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Embodiment 1

[0139] Gel formulation containing calcipotriol and betamethasone

[0140] To prepare 1 kg of gel formulation, 30 g of hydrogenated castor oil were melted together with 749 g of heptamethylnonane at 85-90°C and cooled to about 60°C with homogenization. The mixture was then cooled to 25-30°C with stirring. 643 mg of betamethasone dipropionate suspended in 50 g of heptamethylnonane was added to the homogenized gel matrix. Dissolve 52.2 mg of calcipotriol hydrate or 50 mg of calcipotriol in 170 g of polyoxypropylene-15-stearyl ether and add to the mixture of other ingredients to homogenize the preparation to ensure uniform distribution of the active ingredient. The resulting gel formulation was stable when stored at 40°C for 3 months, indicating a shelf life of at least 2 years at room temperature. Stability data are shown in Tables 1 and 2 below.

[0141] Table 1

[0142]

[0143] Start at 5°C / 1 month

40℃...

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Abstract

The present invention relates to a pharmaceutical gel composition for application to the skin, said composition comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid and a viscosity-increasing excipient.

Description

field of invention [0001] The present invention relates to topical compositions for application to the skin comprising at least one vitamin D or vitamin D analog and at least one corticosteroid. Background of the invention [0002] In the treatment of a large number of disorders by skin application, for example in the treatment of psoriasis, combination therapies are often employed, in which two or even more different pharmacologically active compounds are combined. Thus, for example, in the treatment of psoriasis, it is known to use combination therapy involving a steroid compound, such as a corticosteroid compound, and a vitamin D analogue, such as calcipotriol, wherein each active compound is formulated in a separate formulations because of the instability of corticosteroids at alkaline pH and the instability of vitamin D analogs at acidic pH. [0003] Physicians are therefore obliged to subject patients to this type of two-component regime, a sequential administration o...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/00A61K31/573A61K31/59A61K45/06A61K47/00A61K47/06A61K47/10A61K47/14A61K47/32A61K47/34A61K47/44A61P17/06
CPCA61K9/0014A61K31/59A61K47/06A61K47/10A61K47/44A61P17/00A61P17/06A61P43/00A61K31/57A61K2300/00
Inventor G·霍伊E·J·狄德里克森
Owner LEO PHARMA AS
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