Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids

An aryl and alkyl technology, which is used in the field of preparation of highly functionalized γ-butyrolactam and γ-amino acid
CN1649827AInactive Publication Date: 2005-08-03WARNER-LAMBERT CO
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WARNER-LAMBERT CO
Publication Date
2005-08-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a process for preparing highly functionalized gamma- butyrolactams and gamma-amino acids by reductive amination of mucohalic acid or its derivatives, and discloses a process for preparing pregabalin or 3-aminomethyl-5-methyl octanoic acid, GABA analogs with desirable medicinal activity. (Formula I).
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of priority to US Provisional Patent Application No. 60 / 376991, filed April 30,2002. field of invention

[0003] The present invention relates to a process for the preparation of highly functionalized γ-butyrolactams and γ-amino acids by reductive amination of mucohalic acid or its derivatives, and discloses the preparation of GABA analogues fugabalin with the desired pharmaceutical activity (pregabalin) method. Background of the invention

[0004] Fugabalin (3-aminomethyl-5-methyl-hexanoic acid) is a 3-substituted analogue of gamma-aminobutyric acid (GABA) which exhibits an array of useful medical properties, as described in WO93 / 23383, and U.S. Patent As disclosed in No. 6306910 and WO 00 / 76958, the latter two documents are assigned to the same assignee as the present application.

[0005]

[0006] ric...

Claims

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