2 results about "GABA analogue" patented technology

The invention discloses a chiral pentafluorophenyl urea compound as well as a preparation method and application thereof, and relates to a preparation method and application of a synthetic drug. The synthesized chiral product is used for synthesizing GABA analogue drugs such as (R)-pheibut, (R)-baclofen and the like, an effective method is provided for chiral drug synthesis, and the application of the chiral product in catalysis of asymmetric addition reaction of dithiomalonate and nitroolefin in a water-containing medium is provided. When pentafluorophenylurea catalyzes an asymmetric addition reaction of dithiomalonate and nitroolefin in a water-containing solvent, due to a hydrophobic hydration effect, the reaction rate and stereoselectivity of pentafluorophenylurea are remarkably improved compared with those of pentafluorophenylurea in an organic solvent, the dosage of a catalyst can be remarkably reduced, and green chemical requirements are met.

The present application relates to gamma aminobutyric acid analogues and methods of making and using the same. The gamma aminobutyric acid analogues include a gamma aminobutyric acid moiety and a polyethylene glycol (PEG) moiety. The gamma aminobutyric acid analogues of the present application are active GABA analogues that promote proliferation of pancreatic beta cells and secretion of insulin, have similar in vivo functions as GABA, improve in vivo metabolic characteristics relative to GABA, and are useful as drug substitutes for treating metabolic and neurological diseases.