Liquid pharmaceutical composition

A technology of liquid medicine and composition, applied in the field of treating subjects suffering from the following diseases, capable of solving problems such as gabapentin bitterness
CN1509165AInactive Publication Date: 2004-06-30WARNER LAMBERT CO LLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WARNER LAMBERT CO LLC
Publication Date
2004-06-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention describes liquid pharmaceutical compositions of GABA analogs having a pH of from about 5.5 to about 7.0 comprising at least one polyol containing 2 to 6 carbon atoms and also discloses comprising a first ingredient and a second ingredient two-component liquid pharmaceutical compositions, wherein the first component comprises a powder mixture containing GABA analogs and a solid polyol, and the second component comprises a liquid base; the present invention also describes the use of these compositions. Methods of making and using therapeutically effective amounts of the pharmaceutical compositions to treat the following disorders: Brain disorders, including epilepsy, fainting episodes, hypokinesia, and intracranial trauma; neurodegenerative disorders; depression; mania and bipolar disorder Disorders; anxiety; panic; inflammation; renal colic; insomnia; gastrointestinal impairment; incontinence; pain, including neuropathic pain, myalgia, bone pain, and migraine.
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Description

field of invention

[0001] The present invention relates to liquid pharmaceutical compositions comprising gamma-aminobutyric acid (GABA) analogs, methods for their preparation, and methods of using such compositions to treat subjects, including human subjects, suffering from certain brain Illness, including epilepsy, fainting episodes, hypokinesia, and intracranial trauma; neurodegenerative disease; depression; mania and bipolar disorder; anxiety; panic; inflammation; renal colic; insomnia; gastrointestinal impairment; incontinence ; Pain, including neuropathic pain, myalgia, skeletal pain, and migraine. Background of the invention

[0002] GABA is an inhibitory amino acid found in the mammalian central nervous system (CNS). It has been reported that dysfunction of GABA neurotransmission in the CNS can produce and even lead to psychosis and neurological diseases, such as epilepsy, schizophrenia, Parkinson's disease, Huntington's disease and hypokinesia (Saletu B. et al., Int...

Claims

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