Nano-magnetic microsphere and nona-magnetic immuno-microsphere, and preparing process and application thereof

A nano-magnetic and immune microsphere technology, applied in the field of pharmacy, can solve the problems that cannot be used in the field of biology

Inactive Publication Date: 2005-10-26
SHENZHEN PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It generally cannot be used in the biological field

Method used

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  • Nano-magnetic microsphere and nona-magnetic immuno-microsphere, and preparing process and application thereof
  • Nano-magnetic microsphere and nona-magnetic immuno-microsphere, and preparing process and application thereof
  • Nano-magnetic microsphere and nona-magnetic immuno-microsphere, and preparing process and application thereof

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Experimental program
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Embodiment Construction

[0071] Implementation Proceedings 1: Get 30mg of carbon-coated iron nano-magnetic powder (produced by Shenzhen Zunye Nano Materials Co., Ltd., model JY-FeC, with an average particle diameter of 25nm and a maximum particle diameter of 60nm), 50mg of chitosan (Jinan Haidebei Provided by Marine Bioengineering Company, deacetylation degree > 95.7%) was dissolved in 5ml of HAC (6%), ultrasonically mixed, and 0.5ml of 15% glutaraldehyde aqueous solution was added dropwise. Then, under the above-mentioned suspension ultrasonic and stirring condition, dropwise drop (within 10min) the preconfigured toluene solution, namely 20gAOT is dissolved in the 50ml toluene (the described AOT is aerosol OT, molecular formula is C 20 h 37 NaO 7 S, the molecular weight is 444.56, purchased by Shanghai Jufeng Chemical Technology Co., Ltd., produced by Jiashan Jufeng Chemical Factory, the soap price is 220-225). Continue ultrasonic stirring for 15 min. After 4 hours, stop stirring, wash with ethano...

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Abstract

This invention discloses a nm magnetic microsphere and a nm magnetic immune microphere, their preparation method, (inverse micro-emulsion) its usage and its pharmaceutical composition, among which, said nm microsphere contains a macromolecular packed layer formed by chemical-cross linking with a degradable macromolecular material containing amino-group, the packed layer contains nm magnetic material, the mean size of the microspheres is 20-80nm. The nm magnetic immune microsphere with nm magnetic microsphere as the core is connected with a bioactive subject on the surface. Said nm magnetic microshpere is generated by the reaction of nm magnetic material, macromolecular material and the crosslinker in the inverse micro-emulsion.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a nano-magnetic microsphere and a nano-magnetic immune microsphere and their preparation method (inverted microemulsion method) and application, and also relates to a nano-magnetic microsphere or a nano-magnetic immune microsphere Balls of pharmaceutical composition. Background technique [0002] Since the 1970s, magnetic immune microspheres have rapidly been widely promoted and applied in the separation and purification of cells, the separation and detection of microorganisms, the detection and separation of biologically active substances, and cytotoxicity. Magnetic polymer microspheres are mainly prepared by coating a layer of polymer on the surface of magnetic metal or oxide nanoparticles by physical or chemical methods. These polymers mainly include vinyl monomers of styrene and monomers containing chemical functional groups (one or more of acrylamide, acrylic acid, metha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/10
Inventor 李富荣周汉新曹君剑齐晖任莉莉
Owner SHENZHEN PEOPLES HOSPITAL
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