Povidone iodine effervescence tablet for treating milk cow colpitis, its preparation process and application

Abstract

The invention provides a Povidone iodine effervescent tablet for preventing and treating cow's vaginitis, which is prepared from Povidone iodine, tartaric acid, sodium hydrogen carbonate, cross bonding polyvinylpyrrolidone, miropowdered silica gel, sodium dodecylsulfate, magnesium stearate, sodium chloride or lactose through dry method palletizing and pelleting.

Description

technical field

[0001] The invention belongs to the technical field of veterinary drug preparation, in particular to a povidone-iodine effervescent tablet for treating cow vaginitis, a preparation method and application thereof. Background technique

[0002] Cow vaginitis is a common disease of dairy cows, often secondary to uterine inflammation, leading to infertility or low conception rate of dairy cows, reducing milk production of dairy cows, and causing serious economic losses. Cow vaginitis is mainly caused by bacteria, chlamydia, fungi, viruses and trichomonas. In the past, antibiotics or traditional Chinese medicine were used for treatment. However, antibiotic treatment is easy to cause bacterial drug resistance, and Chinese medicine treatment is slow to take effect and cannot fundamentally solve this problem. Dosage forms such as lotions, suppositories, and gels are released and only exert their drug effects locally and cannot reach t...

Examples

Embodiment 1

[0034] Prepare 1000 kilograms of povidone-iodine effervescent tablets The physical addition of each component is as follows:

[0035] Povidone-iodine 80kg

[0036] Tartaric acid 200kg

[0037] Sodium bicarbonate 400kg

[0038] Cross-linked polyvinylpyrrolidone 100kg

[0039] Micropowder silica gel 20kg

[0040] Sodium Lauryl Sulfate 20kg

[0041] Magnesium Stearate 5kg

[0042] Lactose 175kg

[0043] It is prepared as follows:

[0044] (1) The components of the above formula are dried, passed through a 100 mesh sieve, and set aside;

[0045] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with half the amount of the above formula, fully mix with tartaric acid, and carry out dry granulation, Pass through a 20-mesh sieve to obtain A grain;

[0046] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with a quarter of the above-mention...

Embodiment 2

[0051] The amount of addition in kind of each component of preparing 1000 kilograms of pharmaceutical compositions is as follows:

[0052] Povidone-iodine 133kg

[0053] Tartaric acid 187.6kg

[0054] Sodium bicarbonate 375.2kg

[0055] Cross-linked polyvinylpyrrolidone 200kg

[0056] Micropowder silica gel 30kg

[0057]Sodium Lauryl Sulfate 20kg

[0058] Magnesium Stearate 10kg

[0059] Sodium chloride 44.2kg

[0060] It is prepared as follows:

[0061] (1) The components of the above formula are dried, passed through a 120 mesh sieve, and set aside;

[0062] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, sodium chloride and cross-linked polyvinylpyrrolidone with half of the above-mentioned formula amount, fully mix with tartaric acid and carry out dry method Granules were passed through a 16-mesh sieve to obtain A grains;

[0063] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, sodium chloride and cross-linked polyv...

Embodiment 3

[0068] The amount of addition in kind of each component of preparing 1000 kilograms of pharmaceutical compositions is as follows:

[0069] Povidone-iodine 326.8kg

[0070] Tartaric acid 163.5kg

[0071] Sodium bicarbonate 327kg

[0072] Cross-linked polyvinylpyrrolidone 100kg

[0073] Micropowder silica gel 30kg

[0074] Sodium Lauryl Sulfate 20kg

[0075] Magnesium Stearate 10kg

[0076] Lactose 22.7kg

[0077] It is prepared as follows:

[0078] (1) The components of the above formula are dried, passed through a 120 mesh sieve, and set aside;

[0079] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with half the amount of the above formula, fully mix with tartaric acid, and carry out dry granulation, Pass through a 16-mesh sieve to obtain A grain;

[0080] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with a quarter of the a...

technical field

[0001] The invention belongs to the technical field of veterinary drug preparation, in particular to a povidone-iodine effervescent tablet for treating cow vaginitis, a preparation method and application thereof. Background technique

[0002] Cow vaginitis is a common disease of dairy cows, often secondary to uterine inflammation, leading to infertility or low conception rate of dairy cows, reducing milk production of dairy cows, and causing serious economic losses. Cow vaginitis is mainly caused by bacteria, chlamydia, fungi, viruses and trichomonas. In the past, antibiotics or traditional Chinese medicine were used for treatment. However, antibiotic treatment is easy to cause bacterial drug resistance, and Chinese medicine treatment is slow to take effect and cannot fundamentally solve this problem. Dosage forms such as lotions, suppositories, and gels are released and only exert their drug effects locally and cannot reach t...

Examples

Embodiment 1

[0034] Prepare 1000 kilograms of povidone-iodine effervescent tablets The physical addition of each component is as follows:

[0035] Povidone-iodine 80kg

[0036] Tartaric acid 200kg

[0037] Sodium bicarbonate 400kg

[0038] Cross-linked polyvinylpyrrolidone 100kg

[0039] Micropowder silica gel 20kg

[0040] Sodium Lauryl Sulfate 20kg

[0041] Magnesium Stearate 5kg

[0042] Lactose 175kg

[0043] It is prepared as follows:

[0044] (1) The components of the above formula are dried, passed through a 100 mesh sieve, and set aside;

[0045] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with half the amount of the above formula, fully mix with tartaric acid, and carry out dry granulation, Pass through a 20-mesh sieve to obtain A grain;

[0046] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with a quarter of the above-mention...

Embodiment 2

[0051] The amount of addition in kind of each component of preparing 1000 kilograms of pharmaceutical compositions is as follows:

[0052] Povidone-iodine 133kg

[0053] Tartaric acid 187.6kg

[0054] Sodium bicarbonate 375.2kg

[0055] Cross-linked polyvinylpyrrolidone 200kg

[0056] Micropowder silica gel 30kg

[0057]Sodium Lauryl Sulfate 20kg

[0058] Magnesium Stearate 10kg

[0059] Sodium chloride 44.2kg

[0060] It is prepared as follows:

[0061] (1) The components of the above formula are dried, passed through a 120 mesh sieve, and set aside;

[0062] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, sodium chloride and cross-linked polyvinylpyrrolidone with half of the above-mentioned formula amount, fully mix with tartaric acid and carry out dry method Granules were passed through a 16-mesh sieve to obtain A grains;

[0063] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, sodium chloride and cross-linked polyv...

Embodiment 3

[0068] The amount of addition in kind of each component of preparing 1000 kilograms of pharmaceutical compositions is as follows:

[0069] Povidone-iodine 326.8kg

[0070] Tartaric acid 163.5kg

[0071] Sodium bicarbonate 327kg

[0072] Cross-linked polyvinylpyrrolidone 100kg

[0073] Micropowder silica gel 30kg

[0074] Sodium Lauryl Sulfate 20kg

[0075] Magnesium Stearate 10kg

[0076] Lactose 22.7kg

[0077] It is prepared as follows:

[0078] (1) The components of the above formula are dried, passed through a 120 mesh sieve, and set aside;

[0079] (2) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with half the amount of the above formula, fully mix with tartaric acid, and carry out dry granulation, Pass through a 16-mesh sieve to obtain A grain;

[0080] (3) Take povidone-iodine, micropowder silica gel, sodium lauryl sulfate, lactose and cross-linked polyvinylpyrrolidone with a quarter of the a...