Use of morpholine methyltetralone in preparation of smooth muscles spasmolytic

Abstract

The invention relates to the use of CY in preparing smooth muscle spasmolysis agent, and in preparing medicaments for treating stomach and intestinal spasm colicky pain, intestine excitable syndrome, ulcerative colitis, stomach and intestine dysfunction, and functional diarrhea.

Description

Technical field: The invention relates to the technical field of medicine, in particular to the use of morpholine methyltetralone (CY) for preparing a smooth muscle antispasmodic agent. Background technique The chemical name of CY is morpholine methyltetralone (3,4-dihydro-2-(4-morpholinylmethyl)-1(2H)-naphthalenone), the compound in 1977 by Welch, Willard M.; Harbert, Charles A.; Sarges, Reinhard; Stratten, Wilford P. ; Weissman, et al successfully synthesized and investigated its analgesic activity. The results show that the compound has weak analgesic activity, but so far there is no report about the relaxing effect of CY on smooth muscle. The inventors found that the compound has antispasmodic effect on smooth muscle for the first time after various experimental screenings. The chemical system name of morpholine methyl tetralone is 2-(4-morpholine methyl)-1-tetralone, and its synthetic method is as follows Mix 4.20g (0.028mol) of 1-tetralone, 2.50g (0.029mol) of mo...

AI Technical Summary

Problems solved by technology

The results show that the compound has weak analgesic activity, but so far there is no report about the relaxing effect of CY on smooth muscle. The inventors have screened through various experiments and found that the compound has smooth muscle spasmolytic effect for the first time.

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