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Extractive of Hema-ethyl acetate and its action

A technology of ethyl acetate extraction and ethyl acetate, applied in the field of anti-immunosuppression, can solve the problems of white blood cell and platelet amenorrhea and liver damage, limit clinical application, toxic and side effects, etc., to reduce immune damage and prolong survival Time, less toxic and side effects

Inactive Publication Date: 2006-06-14
周亚滨 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the research on tripterygium glycosides is relatively in-depth. Although it has been confirmed that tripterygium glycosides has a certain inhibitory effect on cellular immunity and humoral immunity, the fly in the ointment is the obvious toxic and side effects it brings at the same time, such as gastrointestinal tract Reaction, reduction of white blood cells and platelets, amenorrhea and liver damage, etc., limit its clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0243] Embodiment 1: decocting method

[0244] Put hematoxylin coarse powder through a 40-mesh sieve, soak it with 8 times the amount of water for 4 hours, continuously reflux extraction, combine the two liquids, concentrate the filtrate for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.00-1.05, and use acetic acid ethyl acetate for extraction, the volume ratio is ethyl acetate: water = 1: 1, after shaking vigorously, stand still for 2 hours, separate the upper ethyl acetate layer, extract continuously for 3 times, combine the ethyl acetate layer, and put it in a rotary evaporator Ethyl acetate was recovered under reduced pressure at a temperature of 40°C, the concentrated solution was placed in a vacuum drying oven and dried under reduced pressure to constant weight at a temperature of 40°C to obtain a dry powder of ethyl acetate extract;

Embodiment 2

[0245] Embodiment 2: Ultrasonic vibration extraction

[0246] Pass the hematoxylin coarse powder through a 40-mesh sieve, soak it in 8 times the amount of 75% ethanol for 2 hours, extract it twice with continuous ultrasonic vibration, each time at <50°C for 2 hours, filter, combine the filtrates, recover the ethanol under reduced pressure, and dry to Constant weight, made 75% ethanol extract;

[0247] Take 75% ethanol extract, grind to fine powder, pass through 80 mesh sieve, suspend in water and extract with ethyl acetate, the volume ratio is ethyl acetate: water = 1: 1, after vigorous shaking, stand still for 2 hours, Separate the upper ethyl acetate layer, extract continuously for 3 times, combine the ethyl acetate layers, recover ethyl acetate under reduced pressure in a rotary evaporator, the temperature is 40°C, put the concentrated solution in a vacuum drying oven and dry it under reduced pressure to constant weight , the temperature is 40°C; the ethyl acetate extract ...

Embodiment 3

[0248] Embodiment 3: percolation method

[0249] Pass the hematoxylin coarse powder through a 40-mesh sieve, extract by continuous percolation with 75% ethanol, collect the percolation liquid, recover ethanol under reduced pressure, and dry to constant weight to prepare 75% ethanol extract;

[0250] Take 75% ethanol extract, grind to fine powder, pass through 80-mesh sieve, suspend in water and extract with ethyl acetate, the volume ratio is ethyl acetate: water = 1: 1, after vigorous shaking, stand still for 2 hours , separate the upper ethyl acetate layer, extract continuously for 3 times, combine the ethyl acetate layers, recover ethyl acetate under reduced pressure in a rotary evaporator, the temperature is 40°C, put the concentrated solution in a vacuum drying oven and dry it under reduced pressure until constant Heavy, the temperature is 40 ℃; Obtain dry powder of ethyl acetate extract;

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Abstract

An extract of sapanwood for eliminating the immunological rejection reaction generated by organ transplantation is prepared from sapanwood through extracting by ethyl acetate.

Description

technical field [0001] The invention belongs to a hematoxylin ethyl acetate extract and its effect, specifically the effect on anti-immunosuppression. Background technique [0002] With the development of medicine and the deepening of immunology research, people have gradually realized that the abnormality of the immune system is closely related to the occurrence of many human diseases. Clinical work often requires the use of a large amount of immunosuppressants, especially for patients receiving organ transplantation, which need to be taken for life. [0003] Organ transplantation has been carried out clinically for more than 40 years, and the progress was slow in the early stage due to the trouble of rejection. Since the clinical application of cyclosporine A in 1978, organ transplantation has undergone revolutionary changes. There are four categories of immunosuppressants commonly used in clinical practice: ① chemically synthesized cytotoxics (antimetabolites and alkyla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P37/06B01D11/04
Inventor 周亚滨
Owner 周亚滨
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