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Effervescent of compounding medicines

An effervescent and drug technology, applied in the field of medicine, can solve the problems of patient inconvenience, slow onset of tablet effect, taking a dozen or even dozens of tablets, etc., to achieve convenient administration, enhanced vascular permeability, and reduced freedom The effect of base on myocardial cell injury

Active Publication Date: 2010-12-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Compound Danshen Tablets and Compound Danshen Dropping Pills are currently the most common dosage forms of Compound Danshen preparations. As drugs for treating cardiovascular diseases, these two drugs for treating cardiovascular diseases have their own shortcomings. Although the effect is quicker, for elderly patients with cardiovascular disease who often take it, it is extremely inconvenient for elderly patients to take a dozen or even dozens of pills for each tens of milligrams of drop pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (a): Take 30-180g of salvia miltiorrhiza, 5-40g of notoginseng, 0.3-2.5g of borneol, and 10-500g of effervescent auxiliary materials for later use;

[0053] (b): Take Salvia miltiorrhiza and Panax notoginseng and add water to decoct 1-5 times, combine the decoction, filter, concentrate the filtrate, add 0.5-5 times the amount of 80-99% ethanol, let stand for 12-36 hours, filter and recover ethanol, and the filtrate is concentrated to a thick paste with a relative density of 1.05-1.45 under the condition of 30-80° C. to obtain the extracts of Danshen and Panax notoginseng.

Embodiment 2

[0055] (a): Take 90g of Salvia miltiorrhiza, 17.6g of Panax notoginseng, 0.5g of borneol, 12g of xylitol, 3g of xanthan gum, 30g of sodium bicarbonate, 10g of starch, and 20g of citric acid for later use;

[0056] (b): Take Danshen and Panax notoginseng and add water to decoct three times, combine the decoctions, filter, concentrate the filtrate, add 2 times the amount of 95% ethanol, let it stand for 24 hours, filter, recover the ethanol, and concentrate to a relative density of 1.33-1.35 (55~60℃) Danshen and Panax notoginseng extract;

[0057] (c): Dissolve 1 g of borneol in an appropriate amount of ethanol, add salvia miltiorrhiza, Radix Notoginseng extract, xylitol, xanthan gum, sodium bicarbonate, starch, fully mix, dry, sieve, and granulate to obtain a spare product ;

[0058] (d): Add citric acid to the preparation, mix well, and press into tablets to make effervescent tablets of 1g each, to obtain.

Embodiment 3

[0060] (a): Take 150g of salvia miltiorrhiza, 20g of notoginseng, 1.5g of borneol, 20g of xylitol, 5g of pregelatinized starch, 25g of sodium bicarbonate, 9g of starch, and 30g of citric acid for later use;

[0061] (b): Take 150g of Salvia miltiorrhiza and 20g of Panax notoginseng, add water to decoct twice, combine the decoction, filter, concentrate the filtrate, add 4 times the amount of 85-95% ethanol, let it stand for 36 hours, filter, recover the ethanol, concentrate the filtrate To a clear paste (1) with a relative density of 1.10-1.25 under the condition of 70-80°C;

[0062] (c): Take 1.5g of borneol and dissolve in an appropriate amount of ethanol, add salvia miltiorrhiza, Radix Notoginseng extract, xylitol, pregelatinized starch, sodium hydrogen acid acid, starch, fully mix, dry, sieve, granulate, get spares;

[0063] (d): Add citric acid to the preparation, mix well, and press into tablets to make effervescent tablets of 1g each, to obtain.

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Abstract

A composite medicine in the form of effervescent tablet for treating cardiovascular and cerebrovascular diseases is disclosed. It is especially suitable for old patients.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an effervescent tablet made from traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease. It is a disease with high morbidity and mortality and seriously endangers the health of human beings, so it is called "the first killer of human beings". Traditional Chinese medicine has a long history of treating these diseases, especially single or compound preparations with Salvia miltiorrhiza as the main raw material have definite curative effects. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K36/258A61K9/46A61K9/20A61P9/10A61K31/045
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD