Medicine for treating cardiac insufficiency

Abstract

A medicine for acute or chronic cardiac disfunction is disclosed. Its advantages are high natural level and safety and low toxic by-effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical preparation for treating acute and chronic cardiac insufficiency made from traditional Chinese medicines. Background technique [0002] Icy anthocyanins are the total glycosides extracted from Adonis amurensis Regel et Radde, a plant of Ranunculaceae. It has the effects of strengthening the heart, diuresis, sedation, and slowing down the heart rate. It is used for acute and chronic heart insufficiency. [0003] Adonlsldum tastes bitter, has hygroscopicity, and is easily soluble in water, but its tablet disintegration time is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of excipients is large, and there are also reports in the literature Mix ice-cold anthocyanin with appropriate amount of polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol ...

AI Technical Summary

Problems solved by technology

[0003] Adonlsldum tastes bitter, has hygroscopicity, and is easily soluble in water, but its tablet disintegration time is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of excipients is large, and there are also reports in the literature Add ice-cold flower glycosides with appropriate amount of polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol 1500, polyethylene glycol 1000, sodium stearate, glycerin gelatin, poloxamer, stearic acid, monostearate Glyceric acid, insect wax, etc. made into drop pills

Dropping pill preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparation generally faces the following problems: 1. The pure natural degree of drop pill auxiliary materials is not high: Pill base excipients are mostly chemical synthetic products with a low degree of naturalness. It is very difficult to find new alternative base excipients, especially those with a high degree of naturalness and the determination of their preparation process, because currently common The preparation conditions required for the possible substitutes of natural matrix excipients are very harsh, and the temperature of the excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food ...