Determination of a measure of a glycation end-product or disease state using tissue fluorescence

A tissue, state technology, applied in the field of using tissue fluorescence to determine a certain glycation end product or disease state, which can solve problems such as technologies or methods that do not mention variable properties

A tissue, state technology, applied in the field of using tissue fluorescence to determine a certain glycation end product or disease state, which can solve problems such as technologies or methods that do not mention variable properties

CN1882278AInactive Publication Date: 2006-12-20VERALIGHT INC
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  • Determination of a measure of a glycation end-product or disease state using tissue fluorescence
  • Determination of a measure of a glycation end-product or disease state using tissue fluorescence
  • Determination of a measure of a glycation end-product or disease state using tissue fluorescence

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Embodiment Construction

[0043] Exposure of proteins to glucose generally results in non-enzymatic glycation and sugar oxidation, a process known as the Maillard reaction. The stable end products of the Maillard reaction are collectively referred to as advanced glycation end products (AGEs). In the absence of significant clearance, the AGEs accumulate at a rate proportional to mean blood glucose levels. The Maillard reaction can be thought of as an aging process that occurs regularly in the healthy state and is accelerated in diabetic patients by the presence of chronic hyperglycemia. In the skin, collagen is the most abundant protein and is susceptible to glycation. Skin collagen AGEs are usually in the form of fluorescent cross-links and adducts; pentosidine (cross-link) and carboxymethyllysine (CML, adduct) are two well-studied skin- Collagen AGE example. Other AGE examples include fluorolink, pyrraline, crossline, N'..-(2-carboxyethyl)lysine (CEL), glyoxal-lysine dimer (GOLD), methylethyl Dial...

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Abstract

A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue (for example, the reflectance of the tissue). Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority under 35 U.S.C § 120 to U.S. Patent Application No. 10 / 116,272, entitled "Apparatus And Method For Spectroscopic Analysis Of Tissue To Detect Diabetes In An Individual," filed April 4, 2002 (cited by Incorporated herein), and claiming that the U.S. Provisional Application No. 60 / 515,343, filed on October 28, 2003, entitled "Determination of a Measure of a Glycation End-Productor Disease State Using Tissue Fluorescence" (by reference manner incorporated herein). technical field [0003] The present invention generally relates to determination of tissue state from tissue fluorescence. More specifically, the present invention relates to a method and apparatus for determining a model relating tissue fluorescence to tissue state, a method and apparatus for determining tissue fluorescence properties, and a method and apparatus for determining tissue state through fluorescence properties and an ...

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Application Information

Patent Timeline
20 Dec 2006
Publication
CN1882278A
IPC
A61B5/00
CPC
A61B5/0068; A61B5/0071; A61B5/0075; A61B5/0066
Inventors
L·爱德华·赫尔; 尼尔·埃迪吉尔·马伍德