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Jinganmin oral disintegrant tablets and preparation thereof

A technology for Jin-sensitivity oral and orally disintegrating tablets, which is applied in the field of Jin-sensitivity orally-disintegrating tablets and their preparation, and can solve the problems of no reports of Jin-sensing orally-disintegrating tablets being found.

Inactive Publication Date: 2011-10-12
HONGMEI PHARMA CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the data search, no reports about Jin Sensing orally disintegrating tablets were found

Method used

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  • Jinganmin oral disintegrant tablets and preparation thereof
  • Jinganmin oral disintegrant tablets and preparation thereof
  • Jinganmin oral disintegrant tablets and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Prescription: 250g of aspirin, 100g of amantadine hydrochloride, 15g of caffeine, 2g of chlorpheniramine, 10g of artificial bezoar, 500g of honeysuckle, and 500g of Daqingye.

[0061] (2) Preparation of the main ingredient: get the honeysuckle medicinal material, pulverize it, cross a 40-mesh sieve, add 70% hydrochloric acid ethanol solution of 4 times the amount of pH3 and soak for half an hour, put it into an ultrasonic extraction tank, and carry out ultrasonic vibration extraction for 20 minutes. Oscillation frequency 30kHz, extraction twice, combined extracts, filtered, filtrate under 50 ℃ under reduced pressure to recover ethanol, dried, crushed to obtain honeysuckle extract; take Daqingye medicinal material, crushed, passed through a 20 mesh sieve, added 5 times Reflux extraction with 80% ethanol for 2 times, each time for 1 hour, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure, dry, and pulverize to obtain the Fol...

Embodiment 2

[0070] (1) Prescription: 250g of aspirin, 100g of amantadine hydrochloride, 15g of caffeine, 2g of chlorpheniramine, 10g of artificial bezoar, 500g of honeysuckle, and 500g of Daqingye.

[0071] (2) Preparation of the main ingredient: get the honeysuckle medicinal material, pulverize it, pass through a 40-mesh sieve, add 80% hydrochloric acid ethanol solution of 8 times the amount of pH4 and soak for half an hour, put it into an ultrasonic extraction tank, and carry out ultrasonic vibration extraction for 30 minutes. Oscillation frequency 40kHz, extract 3 times, combine extracts, filter, filtrate recovers ethanol under reduced pressure below 50°C, dry, grind to obtain honeysuckle extract; Reflux extraction with 90% ethanol for 2 times, 1 hour each time, combine the extracts, filter, recover the ethanol from the filtrate under reduced pressure, dry, and pulverize to obtain the Folium Folium extract; , amantadine hydrochloride, caffeine, chlorpheniramine, and artificial bezoar a...

Embodiment 3

[0080] (1) Prescription: 250g of aspirin, 100g of amantadine hydrochloride, 15g of caffeine, 2g of chlorpheniramine, 10g of artificial bezoar, 500g of honeysuckle, and 500g of Daqingye.

[0081] (2) preparation of main ingredient: get honeysuckle medicinal material, pulverize, cross 40 mesh sieves, add 75% hydrochloric acid ethanol solution of 6 times amount pH3. Minutes, oscillation frequency 35kHz, extraction 2 times, combined extracts, filtered, filtrate under 50 ℃ under reduced pressure to recover ethanol, dried, crushed to obtain honeysuckle extract; 6 times the amount of 85% ethanol reflux extraction twice, each time for 1 hour, combined extracts, filtered, the filtrate was decompressed to recover ethanol, dried, crushed to obtain the Folium Folium extract; Mix with aspirin, amantadine hydrochloride, caffeine, chlorpheniramine, and artificial bezoar to obtain 459 g of the main drug.

[0082] (3) The preparation prescription is:

[0083] Main drug 459g

[0084] Cross-l...

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Abstract

A 'Jinganmin' oral disintegrating tablet with high curative effect is proportionally prepared from master medicine, disintegrant, filler, lubricant, and flavouring.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a gold sensitive orally disintegrating tablet and a preparation method thereof. technical background [0002] The patent document with the application number CN200410096174.9 discloses a pharmaceutical composition for treating colds and upper respiratory tract infections, its preparation method and its use. This pharmaceutical composition is called Jin Sensin. Jin Senmin is a Chinese and Western medicine compound preparation prepared from aspirin, amantadine hydrochloride, caffeine, chlorpheniramine, artificial bezoar, honeysuckle, and Folium foliage. It has antipyretic and analgesic effects. Among them, aspirin, Amantadine hydrochloride, caffeine, and chlorpheniramine are western medicines, the effects of each component complement each other, and the therapeutic effect is clear; artificial bezoar also has a good heat-clearing and detoxifying effect, and is a commonl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20
Inventor 杨尚华
Owner HONGMEI PHARMA CHINA
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