Method of external assistant identifying intestinal-type gastric cancer and differentiation degree thereof and special reagent case

A technology for identifying intestines and kits, applied in biochemical equipment and methods, analytical materials, microbial determination/testing, etc., can solve problems such as inability to accurately reflect gene and protein metabolism, limited value, etc.

Inactive Publication Date: 2007-02-07
CAPITALBIO CORP +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tumor cell lines do not accurately reflect how genes and proteins are metabolized in humans and are therefore of limited value

Method used

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  • Method of external assistant identifying intestinal-type gastric cancer and differentiation degree thereof and special reagent case
  • Method of external assistant identifying intestinal-type gastric cancer and differentiation degree thereof and special reagent case
  • Method of external assistant identifying intestinal-type gastric cancer and differentiation degree thereof and special reagent case

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0084] The expression of genes in gene families A and B in gastric tumor tissue relative to gastric normal tissue more than 5 cm away from the tumor margin is shown in Table 1:

[0085] Table 1: Genes in gene families A and B are positively expressed in gastric tumor tissue relative to the stomach more than 5 cm from the tumor margin

[0086] Gene library number

gene name

gene expression

relative abundance

chromosome location

1

NM_000798

DRD5

0.06

4p16.1

2

NM_001438

ESRRG

0.07

3

NM_000705

ATP4B

0.10

13q34

4

NM_005136

KCNE2

0.11

21q22.12

5

NM_001275

CHGA

0.12

14q32

6

NM_005672

PSCA

0.13

8q24.2

7

NM_002630

PGC

0.17

6p21.3-p21.1

8

NM_016362

GHRL

0.18

3p26-p25

9

NM_003837

FBP2

0.19

9q22....

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Abstract

the invention discloses a verifying method of gastrointestinal gastric cancer and differential degree and specific agent box, which adopts expressive level of at least one gene in the list 1, list 2, list 3 and list 4.

Description

technical field [0001] The invention relates to a method and a special kit for auxiliary identification of intestinal type gastric cancer and its degree of differentiation in vitro. Background technique [0002] The methods of diagnosing and treating tumors are mainly based on tissue biopsy or other methods of anatomy. Patients are diagnosed when the tumor has space-occupying lesions and obvious clinical symptoms, and the diagnosis mainly depends on image analysis and pathological morphology. At this time, the vast majority of patients have developed into middle and advanced tumors, and it is difficult to receive effective treatment. On the other hand, clinically, there is often a lack of an effective method to monitor the progress of tumors, especially the lack of a set of objective criteria for selecting appropriate treatment options, which often leads to inappropriate or overtreatment. Therefore, one of the goals of tumor diagnosis and treatment is to establish and deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N33/574
CPCC12Q1/6886C12Q2600/112C12Q2600/158
Inventor 吕有勇郭瑞芳臧师竹张亮任永红庄永龙程京
Owner CAPITALBIO CORP
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