Nasal cavity gel contg. membendazole, and its new use

A technology of mebendazole and gel, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc., can solve problems such as poor treatment effect, achieve high efficiency and prevent recurrence

Inactive Publication Date: 2007-02-14
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0069] 3. If the general treatment effect is not good
So far, there have been no reports or literature records on the use of mebendazole for the treatment of allergic rhinitis, chronic rhinitis, chronic sinusitis, adenoid hypertrophy, nasal polyps or the prevention of recurrence of nasal polyps at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Example 1 Preparation of Mebendazole Nasal Gel Using Carbopol

[0101] Weigh 2 g of Carbopol 940 (Carbopol 940); take 100 ml of sterile distilled water at about 80°C; add Carbopol to the hot water while stirring, add all of Carbopol, and continue stirring for 12 hours. After the temperature is lowered, add 100 mg of mebendazole, then add an appropriate amount of preservative, and stir for 30 minutes to obtain mebendazole gel, which is divided into nasal spray bottles or nasal drops bottles to obtain mebendazole nasal gel agent.

Embodiment 2

[0102] Example 2 Preparation of Mebendazole Nasal Gel Using Hydroxymethylcellulose

[0103] Weigh 2 g of hydroxymethyl cellulose; take 100 ml of sterile distilled water at about 80°C; add hydroxymethyl cellulose to the hot water while stirring, add all the hydroxymethyl cellulose, and continue stirring for 12 hours. After the temperature is lowered, add 100 mg of mebendazole, then add an appropriate amount of preservative, and stir for 30 minutes to obtain mebendazole gel, which is divided into nasal spray bottles or nasal drops bottles to obtain mebendazole nasal gel agent.

Embodiment 3

[0104] Example 3 Preparation of Mebendazole Nasal Gel Using Hydroxyethyl Cellulose

[0105] Weigh 2g of hydroxyethyl cellulose; take 100ml of sterile distilled water at around 80°C; add hydroxyethyl cellulose to the hot water while stirring, add all the hydroxyethyl cellulose, and continue stirring for 12 hours. After the temperature is lowered, add 100 mg of mebendazole, then add an appropriate amount of preservative, and stir for 30 minutes to obtain mebendazole gel, which is divided into nasal spray bottles or nasal drops bottles to obtain mebendazole nasal gel agent.

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PUM

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Abstract

A nasal gel of vermox for treating allergic rhinitis chronic rhinitis, chronic nasosinusitis, adenoids, nasal polyp, etc is disclosed.

Description

technical field [0001] The present invention relates to use mebendazole to prepare nasal cavity gel, and use the nasal cavity gel of mebendazole to treat allergic rhinitis, chronic rhinitis, chronic sinusitis, adenoid hypertrophy, nasal polyps and nasal polyposis, and is also used in surgical treatment , laser treatment and other means of treatment of nasal polyps to prevent the recurrence of nasal polyps. Background technique [0002] 1. Allergic rhinitis [0003] 1. Introduction to allergic rhinitis [0004] Rhinitis refers to inflammation of the nasal mucosa, manifested as congestion or edema. Patients often experience symptoms such as nasal congestion, runny nose, nasal itching, throat discomfort, and coughing. [0005] When there is inflammation in the nose, a large amount of nasal mucus can be secreted in the nasal cavity, which can turn yellow due to infection. When it flows through the throat, it can cause coughing, and when the amount of nasal mucus is very large,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K9/08A61K9/00A61K9/72A61P11/02
Inventor 郑文婕王鹤尧
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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