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Oil-in-water baicalin nano-milk oral liquid and its preparing process

An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of low bioavailability, low solubility, and reduce the curative effect of baicalin, and achieve the effect of improving solubility, improving solubility, and good solubilization

Inactive Publication Date: 2007-03-07
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Baicalin is one of the active ingredients of Scutellaria baicalensis, a plant in the Labiatae family. It belongs to glucuronides. After distillation and hydrolysis, baicalein and glucuronic acid are produced. Anti-allergic, anti-platelet aggregation and anti-coagulation, etc. In recent years, with the continuous increase in research on baicalin in the world and the gradual deepening of understanding, it is believed that baicalin can reduce tissue ischemia-reperfusion by scavenging oxygen free radicals. Injury, immune regulation, promotion of cell apoptosis, anti-tumor and HIV etc. are all effective in many aspects, and its clinical application is becoming more and more extensive. Currently, the clinically used preparations are tablets and capsules. However, due to the poor solubility of baicalin in water Small, low bioavailability, coupled with fast absorption and elimination of baicalin in the body, its elimination biological half-life of metabolism in rats is only 0.16h, thus reducing the curative effect of baicalin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047]Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.4g of Tween-80, 0.7g of Span-80, and 0.9g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at a room temperature of 20°C, then slowly add distilled water to it, and add distilled water at the same time While stirring manually, the viscosity of the system is small at the beginning. With the increase of distilled water, the system will become viscous. At this time, the system may appear liquid crystal state or water-in-oil nanoemulsion. Continue to add drops and stir constantly. When the system suddenly becomes When it is thin, what is produced at this time is the O / W type nanoemulsion. 0.01g baicalin is directly added, stirred until it is completely dissolved, and finally a stable yellow transparent oil-in-water type baicalin nanoem...

Embodiment 2

[0049] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh Tween-801.8g, Span-800.6g, and liquid paraffin 0.6g, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C, then slowly add distilled water into it, and add distilled water while Stir manually. The viscosity of the system is small at the beginning. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue to add drops and stir continuously. When the system suddenly becomes thinner At this time, what produced at this time was the O / W type nanoemulsion, directly added the baicalin of 0.05g, stirred until all dissolved, and finally obtained a stable yellow transparent oil-in-water type baicalin nanoemulsion oral liquid, called...

Embodiment 3

[0051] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 4.5g of polyoxyethylene hydrogenated castor oil and 0.5g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 22°C, then slowly add distilled water to it, and manually stir while adding distilled water, At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear in a liquid crystal state or a water-in-oil nanoemulsion. Continue to add drops and stir continuously. O / W type nanoemulsion is produced at the time, the baicalin of 0.10g is directly added, stirs until all dissolvings, what finally obtains is stable yellow transparent oil-in-water type baicalin nanoemulsion oral liquid, claims its weight as 10.15 g.

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Abstract

The invention discloses an oil-in-water type baicalin nano milk oral liquid comprising surface active agent, oil, baicalin and distilled water. The preparing process comprises the steps of weighing surface active agent, mixing with co-surfactant, calculating HLB according to HLB of the surface active agent, proportioning ratio with the oil, charging distilled water at 20-25 deg C and stirring sufficiently, charging baicalin proportionally, stirring to fully dissolve the materials, forming stabilized yellow transparent system.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of baicalin medicine with the functions of clearing away heat and detoxification, anti-inflammation, promoting choleresis, lowering blood pressure, diuresis, anti-allergy, regulating immunity, promoting cell apoptosis, and anti-tumor and HIV. A transparent and stable oil-in-water type baicalin nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Baicalin is one of the active ingredients of Scutellaria baicalensis, a plant in the Labiatae family. It belongs to glucuronides. After distillation and hydrolysis, baicalein and glucuronic acid are produced. Anti-allergic, anti-platelet aggregation and anti-coagulation, etc. In recent years, with the continuous increase in research on baicalin in the world and the gradual deepening of understanding, it is believed that baicalin can reduce tissue ischemia-reperfusion by scavenging oxygen free rad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/7048A61P29/00A61P9/12A61P31/12A61P35/00
Inventor 欧阳五庆吴旭锦
Owner NORTHWEST A & F UNIV
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