Antibiotic compound recipe comprising piperacillin

Abstract

The invention involves antibiotic compound recipe containing piperacillin, sulbactam or clavulanic acid, ion chelator which can inhibit the formation of particles chelator, the recipe can be further added in buffering ingredient as stability system, the characteristics of the recipe is that it can be prepared to stable pharmaceutical solutions, and with aminoglycoside antibiotics in the same container are re-prepared to drugs used for complex anti-microbial infection.

Description

Field of invention: [0001] The present invention relates to the antibiotic composition that is made up of piperacillin, sulbactam or clavulanic acid, ion chelating agent and / or buffer component, and the characteristic of this composition is that it can be made into stable solution preparation, and can be combined with aminoglycoside antibiotics Reconstituted into a stable solution in the same container as a drug for controlling microbial infections. technical background: [0002] Piperacillin inhibits the synthesis of bacterial cell walls by inhibiting the activity of D-alanyl-D-alanine transpeptidase (Peptidoglycan transpeptidase) in bacteria. Because mucopeptides are some sugar-containing polypeptides with a network structure, they are composed of N-acetylglucosamine (Glc-NAc) and N-acetylmuramic acid (Mur-NAc) alternately composed of linear glycan chain short peptides, these The high polymer needs to undergo a transpeptide cross-linking reaction under the catalysis of mu...

AI Technical Summary

Problems solved by technology

[0008] One problem with the preparation of Pisulide is that the solution is not very stable at room temperature, and unstable solutions tend to produce particles, especially after rethawing of the Pesulide solution that has been frozen or prepared as a lyophilized powder for reconstitution. solution, and the longer it is left, the more particles will be generated