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Capsules of honeysuckle flower and coptis and preparation thereof

A soft capsule, silver-yellow technology, used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of difficult quality control, insufficient absorption, easy oxidative degradation, etc., and avoid poor sealing conditions. , The effect of reducing the increase of moisture and preventing the reaction

Active Publication Date: 2007-04-04
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the slow disintegration and insufficient absorption of Yinhuang tablets, the curative effect cannot be exerted; Yinhuang injection is inconvenient to use, and the active ingredients are easily oxidatively degraded under solution conditions, the quality is difficult to control, and the curative effect and safety cannot be guaranteed; Granules are inconvenient to take; oral liquids are not easy to carry and transport, and the activity of active ingredients is not easy to maintain
Moreover, it has been reported in the literature that the volatile oil components of honeysuckle also have the effect of clearing heat and detoxifying, but all the above preparations cannot retain the volatile oil components of honeysuckle during the preparation process.
[0004] Application No. 03116421.8, titled "Yinhuang Soft Capsule Preparation and Its Preparation Method", attempted to retain the volatile oil components of Flos Lonicerae, but the Yinhuang Soft Capsules and its preparation method provided by the application could not Therefore, the curative effect of the soft capsules provided by this method cannot be exerted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0045] One, the embodiment of extracting active ingredient honeysuckle volatile oil, chlorogenic acid:

[0046] a. Dry 10kg of honeysuckle, crush it through a 20-mesh sieve, put it into the extraction kettle for extraction, the extraction temperature is 40°C, the pressure is 30MPa; the analysis temperature is 50°C, the pressure is 6MPa, the average flow rate is 120kg / h, and the extraction is 1-3h. Get honeysuckle volatile oil 8.6kg, spare;

[0047] b. Get the above-mentioned honeysuckle drug residues, adopt 95% ethanol for the first time, and adopt 50% ethanol aqueous solution for the last two times, the solid-liquid weight ratio is 1: 12, and the pH of the adjustment solution is about 3, and about 50 ℃ extracts 3 times, combined extracts;

[0048] c. Concentrate the extract until there is no alcohol smell, refrigerate at 4°C, and let stand for 4 hours;

[0049] d. Suction filter the refrigerated extract to obtain a supernatant, and slowly add the supernatant to a polyamide re...

Embodiment 1

[0061] Example 1 Preparation of 1000 Yinhuang soft capsules with 40 mg in terms of chlorogenic acid contains the following components:

[0062] 1. Capsule shell

[0063] Gelatin 100g

[0064] Glycerin 45g

[0065] Distilled water 110g

[0066] Ethylparaben 0.20g

[0067] Ferric oxide 3.0g

[0068] Microcrystalline Cellulose 0.5g

[0069] Sodium Metabisulfite 2.5g

[0070] 2. Liquid medicine (content)

[0071] Raw material name dosage

[0072] Chlorogenic acid 40g

[0073] Volatile oil 30g

[0074] Baicalin 80g

[0075] Palm oil 40g

[0076] Hydrogenated Palm Oil 35g

[0077] Lecithin 18g

[0078] Beeswax 7g

[0079] soybean oil 200g

Embodiment 2

[0080] Example 2 Preparation of 1000 silver yellow soft capsules containing 60 mg of chlorogenic acid contains the following components:

[0081] 1. Capsule shell

[0082] Gelatin 120g

[0083] Glycerin 50g

[0084] Distilled water 120g

[0085] Ethylparaben 0.30g

[0086] Ferric oxide 4.0g

[0087] Microcrystalline Cellulose 1.0g

[0088] Vitamin E 5.0g

[0089] 2. Liquid medicine (content)

[0090] Raw material name dosage

[0091] Chlorogenic Acid 60g

[0092] Volatile oil 40g

[0093] Baicalin 100g

[0094] Palm oil 60g

[0095] Hydrogenated Palm Oil 45g

[0096] Lecithin 30g

[0097] Beeswax 15g

[0098] soybean oil 250g

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PUM

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Abstract

An Yinhuang softgel features that its active components in its core are the volatile oil and chlorogenic acid extracted from honeysuckle flower and the scutelloside extracted from scutellaria root. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule and a preparation method thereof, in particular to a Yinhuang soft capsule mainly composed of honeysuckle and scutellaria baicalensis active ingredients and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Yinhuang preparation is composed of honeysuckle extract and Scutellaria baicalensis extract, and the main components are chlorogenic acid and baicalin. It has the effects of clearing away heat, detoxifying, and soothing the throat. It is used for acute tonsillitis, upper respiratory tract infection, and wind-heat invading the lungs resulting in fever, cough, and sore throat. At present, Yinhuang preparations have been widely used clinically in dosage forms such as tablets, injections, granules, and oral liquids. [0003] Due to the slow disintegration and insufficient absorption of Yinhuang tablets, the curative ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/48A61P11/04
Inventor 郭卫芹张育李国聪高志峰齐新英
Owner CSPC OUYI PHARM CO LTD
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