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Compound douricien medicinal composition and its preparation

A kind of composition, the technology of Beidougen, which is applied in the field of medicine, achieves the effect of simple preparation process, high preparation quality and definite curative effect

Inactive Publication Date: 2007-04-04
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction between the root of the root or its extract and 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half ester or a pharmaceutically acceptable salt thereof, the compatibility group Recipe, preparation of anti-inflammatory, anti-viral, antipyretic, analgesic, immune-enhancing drugs, etc., has not been reported yet

Method used

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  • Compound douricien medicinal composition and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Example 1 Preparation, Identification and Content Determination of Northern Bean Root Extract

[0089] Preparation of pea root extract

[0090] Take 10 kg of bean root, crush it into coarse powder, add 8 times the amount of sulfuric acid aqueous solution (pH1~2), warm soak (55~60°C) twice, each time for 24 hours, filter, combine the filtrates, let stand, After the precipitation is complete, take the supernatant and add carbonic acid to adjust the pH value to 9, let it stand until the precipitation is complete, discard the supernatant, take the precipitate and filter it with suction, wash with a small amount of water until neutral, and dry at 50-60°C to obtain the product.

[0091] Prepare three batches of bean root extract respectively, and the yields are shown in Table 2-1.

[0092] Identification of Bean Root Extract

[0093] Take 0.1g of bean root extract, grind finely, add 10ml of ethyl acetate, shake for 30 minutes, let it stand, take the supernatant as the test ...

Embodiment 2

[0099] The preparation of embodiment 2 BYN for injection, BCN for injection

[0100] 1. Prescription:

[0101] Prescription 1:

[0102] Northern bean root extract 237g (equivalent to 24000g of raw medicinal materials)

[0103] Yanhuning or Chuanhuning 40g

[0104] Polysorbate 80 50g

[0105] Mannitol 300g

[0106] Add sterile water for injection to 3000ml

[0107] A total of 1000 sticks were prepared

[0108] Prescription 2:

[0109] Northern bean root extract 118.5g (equivalent to 12000g of raw medicinal materials)

[0110] Yanhuning or Chuanhuning 40g

[0111] Polysorbate 80 25g

[0112] Mannitol 300g

[0113] Add sterile water for injection to 3000ml

[0114] A total of 1000 sticks were prepared

[0115] Prescription 3

[0116] Northern bean root extract 494g (equivalent to 50000g of raw medicinal materials)

[0117] Yanhuning or Chuanhuning 40g

[0118] Polysorbate 80 100g

[0119] Mannitol 300g

[0120] Add sterile water for injection to 3000ml

[0121] ...

Embodiment 3

[0133] The preparation of embodiment 3 BHN injection, BCN injection

[0134] 1. Prescription:

[0135] Prescription 1

[0136] Northern bean root extract 251g (equivalent to 24000g of raw medicinal materials)

[0137] Yanhuning or Chuanhuning 40g

[0138] Polysorbate 80 50g

[0139] Add water for injection to 5000ml

[0140] A total of 1000 sticks were prepared

[0141] Prescription 2

[0142] Northern bean root extract 251g (equivalent to 24000g of raw medicinal materials)

[0143] Yanhuning or Chuanhuning 20g

[0144] Polysorbate 80 50g

[0145] Add water for injection to 5000ml

[0146] A total of 1000 sticks were prepared

[0147] Prescription 3

[0148] Northern bean root extract 251g (equivalent to 24000g of raw medicinal materials)

[0149] Yanhuning or Chuanhuning 400g

[0150] Polysorbate 80 50g

[0151] Add water for injection to 5000ml

[0152] A total of 1000 sticks were prepared

[0153] 2. Specific steps:

[0154] (1) Dispose of the pipes and conta...

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Abstract

A Chinese medicine in the form of injection of any orally taken form for treating the infection of respiratory tract and digestive system, improving immunity, and preventing tumor is proportionally prepared from Asiatic moonseed rhizome or its extract and the 14-dehydroxy-11,12-didehydro andrographolide-3,19-semiester succinate or its pharmacologically acceptable salt.

Description

1. Technical field [0001] The present invention relates to a kind of medicinal product made from pea root or its extract, 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half ester or its pharmaceutically acceptable salt The pharmaceutical composition, its preparation method and application belong to the technical field of medicine. 2. Background technology [0002] Infectious diseases are diseases caused by viruses, mycoplasma, chlamydia, rickettsia, bacteria, fungi, parasites, etc. It is one of the major clinical diseases and seriously endangers human life and health. The emergence and application of antibiotics have played a huge role in the prevention and treatment of infectious diseases, but at the same time, the abuse of antibiotics has also led to the emergence of a large number of multi-drug resistant strains, new viruses are also emerging, and more and more refractory infections. Compared with antibiotics, many traditional Chinese medicine preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/59A61K31/365A61K31/4709A61P31/00A61P29/00
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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