Process for the optical resolution and recycling of tomoxetine

A atomoxetine, pharmaceutical technology, applied in the field of optical resolution and reuse of atomoxetine, can solve problems such as dangerous solvents
CN1950326AInactive Publication Date: 2007-04-18TEVA PHARMA FINE CHEMI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TEVA PHARMA FINE CHEMI
Publication Date
2007-04-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.
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Description

[0001] Cross References to Related Applications

[0002] This application claims protection of U.S. Provisional Patent Application 60 / 583,641 filed on June 28, 2004, 60 / 609,716 filed on September 14, 2004, 60 / 622,065 filed on Oct. 25, 2004, 60 / 652,330 filed on Feb. 11, 2005, and 60 filed on June 28, 2004 / 583,644, 60 / 652,332 of 2005.2.11 application, 60 / 583,643 of 2004.6.28 application, 60 / 652,331 of 2005.2.11 application, 60 / 666,666 of 2005.3.30 application, 60 / 675,369 of 2005.4.26 application, 2005.6. 9 application with unknown application number (attorney docket number 12670 / 46803), and 2005.6.14 application with unknown application number (attorney docket number 12670 / 47001), the entire contents of which are incorporated herein by reference. field of invention

[0003] The present invention relates to a method for the optical resolution of racemic atomoxetine. The present invention also relates to methods for the recycling of (S)-(+)-tomoxetine. Background of the invent...

Claims

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