Use of ginkgo biloba extract in cholesterol reducing

A technology for lowering cholesterol and extracts, applied in the field of preparing cholesterol-lowering drugs, can solve the problems of staying, unreported, clear effect and mechanism of GBE lowering cholesterol and the like

Inactive Publication Date: 2007-05-02
SHANGHAI BIOCHIP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many literature reports on the effect of GBE on glucose metabolism, but most of the research stays at the level of organism and cytology, and fails to reveal the changes of target cells or gene expression levels of target cells after GBE acts on them and the possible effects of GBE on molecular level. metabolic pathway
[0004] In addition, although it is believed that Ginkgo biloba extract may have a certain effect on lipid metabolism (such as triglyceride), the clear effect and mechanism of GBE lowering cholesterol have not been reported before the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047]The preparation method of ginkgo biloba ketone ester extract is known in the art, such as the methods described in German patents DE-B1767 098, DE-B 2117 429, US patent 5,399,348 and Chinese patent CN1145230.

[0048] Composition and method of application

[0049] The invention also provides a composition containing ginkgo biloba ketone ester extract.

[0050] In the present invention, the ginkgo leaf ketone ester extract can be mixed with (pharmaceutically) acceptable carriers, excipients or diluents by conventional methods to form the pharmaceutical composition or health product composition of the present invention. Such carriers include, but are not limited to: saline, buffer, dextrose, water, glycerol, ethanol, and combinations thereof.

[0051] The pharmaceutical composition or health product composition of the present invention can be solid (such as granules, tablets, freeze-dried powder, suppositories, capsules, sublingual tablets) or liquid (such as oral liquid)...

Embodiment 1

[0074] The preparation of embodiment 1 GBE50

[0075] GBE50 was purchased from Shanghai Xingling Technology Pharmaceutical Co., Ltd. (batch number 20030608), and its preparation method was carried out with reference to Chinese patent ZL99803683.8, which complied with the National Drug Standard WS3-227(Z-028)-2002(Z )”.

[0076] After determination, the composition and ratio of GBE50 ingredients are as follows:

[0077] Ginkgo flavonoids glycosides ≥ 24%, total ginkgo flavonoids ≥ 44%, total ginkgo lactones ≥ 6%, clear active ingredients up to 50%, ginkgolic acid ≤ 5PPM.

Embodiment 2

[0078] Example 2 Effect of GBE50 on cholesterol content in blood

[0079] Determination was carried out according to the instructions of the cholesterol determination kit provided by Shanghai Jiemen Biotechnology Co., Ltd.

[0080] group

Measuring index: blood cholesterol content (mol / L)

normal control group

High fat feed group

High-fat feed+GBE50 group

High-fat feed+VD group

High-fat feed+VD+GBE50 group

1.64±0.06

2.13±0.02*

1.86±0.11

2.52±0.13*

1.92±0.03

[0081] *P<0.01

[0082] The results of statistical analysis of the measurement data of cholesterol content in rat blood showed that the blood cholesterol levels of rats fed high-fat diet group and rats fed high-fat diet plus vitamin D group were significantly higher than those of normal control group and medication group . The blood cholesterol levels of the rats in the high-fat diet plus GBE50 group and the rats in the high-fat diet plus vitamin D plus ...

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PUM

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Abstract

An application of the gingko biloba extract (GBE) in decreasing cholesterol by regulating the crucial enzyme genes associated with the cholesterol metabolism, such as Cyp7alphal, Hmgcr, Ppar and Rxr, is disclosed.

Description

technical field [0001] The present invention relates to the use of ginkgo biloba extract (also known as "gingko biloba composition") in the preparation of cholesterol-lowering drugs. More specifically, the present invention relates to the expression changes of the key enzyme genes of bile synthesis in the liver caused by Ginkgo biloba extract (GBE, Ginkgo biloba Extract). Hydroxylase gene (Cyp7a1), hydroxy-3-methylglutaryl formyl coenzyme gene (Hmgcr), peroxisome proliferator-activated receptor gene (Ppar), and retinoid receptor gene (Rxr) have a down-regulation or up-regulation effect. Background technique [0002] Ginkgo biloba L. is a species of Ginkgo biloba in the family Ginkgoaceae. Its leaves are commonly used Chinese medicinal materials, which have the functions of constricting lung qi, relieving asthma and cough, and relieving turbidity. It can be used for lung deficiency asthma, coronary heart disease, angina pectoris and other diseases. Studies have shown that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K45/06A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P3/06
CPCA61K36/16A61P3/00A61P3/06A61P43/00
Inventor 顾笑梅谢德隆张庆华高崎刘刚张国安肖华胜杨宏钧赵国屏
Owner SHANGHAI BIOCHIP
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