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Extractive of fleece-flower root, composition of Chinese traditional medicine of containing the extractive, and application

An extract and the technology of Polygonum multiflorum, which is applied in the application field of Polygonum multiflorum extract to prepare drugs for the prevention and treatment of atherosclerosis, can solve the problems of serious environmental pollution, cumbersome process steps, and difficult industrialization, and achieve simple process steps, Ease of industrialization, price and environmental protection

Inactive Publication Date: 2011-08-10
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process steps are cumbersome, not easy to industrialize, and the chloroform used is highly toxic and seriously pollutes the environment

Method used

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  • Extractive of fleece-flower root, composition of Chinese traditional medicine of containing the extractive, and application
  • Extractive of fleece-flower root, composition of Chinese traditional medicine of containing the extractive, and application
  • Extractive of fleece-flower root, composition of Chinese traditional medicine of containing the extractive, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] (1) Extraction process: take Polygonum multiflorum medicinal material 10kg, pass through a 14 mesh sieve after crushing, percolate with 80% ethanol of 8 times the medicinal material amount, and concentrate the percolation liquid at 60°C to 1:1 under reduced pressure (1ml is equivalent to 1g medicinal material ), centrifuged and filtered to obtain the supernatant;

[0132] (2) Separation process: pass the supernatant through a polyamide column, first wash the polyamide column with water of 10 times the column volume as the mobile phase; then change 95% ethanol of 5 times the column volume as the mobile phase to obtain an alcohol eluent , The ethanol eluate was concentrated under reduced pressure at 60°C and dried to obtain 243g of Polygonum multiflorum extract. As detected by HPLC, the content of stilbene glycosides in the extract is 60%.

Embodiment 2

[0134] (1) Extraction process: take Polygonum multiflorum medicinal material 10kg, pass through a 14-mesh sieve after crushing, percolate with 80% alcohol 10 times the amount of medicinal material, and concentrate the percolation solution at 60°C to 1:1 under reduced pressure (1ml is equivalent to 1g of medicinal material ), centrifuged and filtered to obtain the supernatant;

[0135] (2) Separation process:

[0136] Pass the supernatant through the AB-8 resin column, first use 5 times the column volume of water as the mobile phase to obtain the water eluent; then replace 10 times the column volume with 30% alcohol as the mobile phase to obtain the alcohol eluent, alcohol The eluate was concentrated under reduced pressure at 60°C to 1:1 (1ml is equivalent to 1g of medicinal material);

[0137] The concentrated solution is passed through a polyamide column, and water of 10 times of the column volume is used as the mobile phase to obtain a water eluent; then, 95% alcohol of 5 t...

Embodiment 3

[0139] (1) Extraction process: take Polygonum multiflorum medicinal material 10kg, pass through a 14-mesh sieve after crushing, percolate with 80% alcohol of 8 times the amount of medicinal material, and concentrate the percolation liquid at 60°C to 1:1 under reduced pressure (1ml is equivalent to 1g of medicinal material ), centrifuged and filtered to obtain the supernatant;

[0140] (2) Separation process:

[0141] Pass the supernatant through a polyamide column, first use 5 times the column volume of water as the mobile phase to obtain a water eluent; then replace 5 times the column volume with 95% alcohol as the mobile phase to obtain an alcohol eluent, and elute with alcohol The solution was concentrated under reduced pressure at 60°C to 1:1 (1ml is equivalent to 1g of medicinal material);

[0142] Pass the concentrated solution through the AB-8 resin column, use 5 times the column volume of water as the mobile phase to obtain the water eluent; then replace 10 times the ...

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Abstract

An extract of fleece flower root containing 2, 3, 5, 4'-tetrahydroxy distyrene-2-0- beta-D-heteroside (not less than 50%) preparing the medicines to prevent and treat atherosclerosis is prepared through conventional extracting, chromatography by polyamide column, eluting, concentrating and drying.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a Polygonum multiflorum extract, a traditional Chinese medicine composition containing the extract and its application in the preparation of drugs for preventing and treating atherosclerosis. Background technique [0002] At present, Chinese herbal medicine has a certain market all over the world. With the increase of people's awareness of health requirements and the aging of the population, sub-health status, people are more eager to return to nature, and use pure natural medicine with high degree of treatment, To prevent problems that cannot be solved by some chemically synthesized drugs, the application of natural herbal medicines is beyond the background of its original national traditional culture. It has become the goal pursued by pharmaceutical companies all over the world to seek medicines with low side effects and high quality and low price from natural medicines...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/70A61P9/10
Inventor 魏峰岳洪水黄芝娟陈庆闯罗崇念胡晨旭
Owner TIANJIN TASLY PHARMA CO LTD
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