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Hydroxy-kojic acid skin peel

a technology of hydroxykojic acid and skin peel, which is applied in the direction of plant growth regulators, biocide, animal husbandry, etc., can solve the problems of direct toxic phenol to the myocardium, hepatotoxic and nephrotoxic, and significant complications of the aforementioned deep phenol peel, so as to achieve safe and efficient peeling

Inactive Publication Date: 2004-08-05
PHYSICIANS CHOICE OF ARIZONA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is a skin peel that uses alpha and beta hydroxy or keto acids as a treatment for hyperpigmentation, melasma, dyschromia, rhytides, photodamage, and aging. The peel can contain hydroquinone or its derivatives and other skin lighteners such as kojic acid or its derivatives. The peel can be used as a deep peel, which penetrates as far as the mid-reticular dermis and causes necrosis of the epidermis and the papillary dermis. However, the present invention is a medium depth peel that penetrates to the upper reticular dermis. The peel is safe and effective and has great utility in dermatologic practice."

Problems solved by technology

Phenol is directly toxic to the myocardium and cardiac arrhythmias have been reported with many phenol peels.
If a high dose is used they are also hepatotoxic and nephrotoxic.
The possibility of complications from the aforementioned deep phenol peels is significant.
Unsightly pigmentary occurrences that may result from the said phenol peels include hyperpigmentation, hypopigmentation, porcelain depigmentation, visible lines of demarcation with unpeeled skin and nevi accentuation.
Medium depth peeling with trichloroacetic acid does not require hospital care and general anesthesia as the phenol deep peels do, nor is there near the number of possible complications and adverse results, however, there is a significant risk of scarring at high concentrations of trichloroacetic acid.
None of the prior art, to applicant's knowledge, discloses a superficial peel utilizing alpha and beta hydroxy or keto acids with kojic acid or its derivatives to treat photodamage, rhytides and pigmentary dyschromias.
Further, prior art relating to therapeutic skin peeling does not disclose use of citric acid, a major component of the Kreb's cycle, tricarboxylic acid cycle or citric acid cycle as it is variously referred to in mammalian metabolism.

Method used

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Examples

Experimental program
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Effect test

example 1

[0047] The following is a general procedure or method for application of the selected superficial or intermediate peels of the present invention which may be applied on a periodic basis:

[0048] a. thorough cleansing of facial skin to be peeled using an appropriate degreaser such as alcohol, acetone, freon or chlorhexidine. Since this is meant to be a superficial type of peel, there is no need to do an aggressive scrub to clean the skin. The goal is to degrease the skin, not to strip off any remaining stratum corneum.

[0049] b. apply light coating of the selected peel (as formulated in the following examples) using a synthetic fiber fan brush or equivalent, starting at the chin and working upwards with particularly thorough coverage of hyperpigmented areas;

[0050] c. apply second coat after 2 to 4 minutes;

[0051] d. apply third and further coats at 2 to 4 minute intervals until appearance of crystals or "frosting";

[0052] e. after appearance of crystals or "frosting", clean face with dist...

example 2

[0057] A therapeutic and prophylactic superficial peel in solution form may be prepared as follows:

[0058] L-lactic acid 14 grams, citric acid 14 grams, salicylic acid 14 grams, and kojic acid 2 grams are dissolved in a mixture of ethanol 40 ml and distilled water 16 ml. and stirred until a clear solution is obtained. The solution should be tightly capped until used.

example 3

[0059] Another therapeutic and prophylactic peel with the addition of the skin lightener hydroquinone may be prepared as follows:

[0060] L-lactic acid 14 grams, citric acid 14 grams, salicylic acid 14 grams, kojic acid 2 grams, and hydroquinone 1 gram are dissolved in a mixture of ethanol 39 ml and distilled water 16 ml. and stirred until a clear solution is obtained. This formulation is appropriate for age spots and keratoses.

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Abstract

The subject of the present invention is a hydroxy-kojic acid skin peel.

Description

[0001] The present application is a continuation-in-part of co-pending U.S. patent application Ser. No. 08 / 328,006 filed Oct. 24, 1994. The entire text of the above-referenced disclosures is specifically incorporated by reference herein without disclaimer.[0002] The present invention relates to skin peels utilizing alpha and beta hydroxy or keto acids as a topical treatment for hyperpigmentation, melasma, dyschromia, rhytides, photodamage and aging. Preferred peels contain alpha and beta hydroxy or keto acids with kojic acid or its derivatives in a dermatologically acceptable carrier such as an ethanoic / water mixture. Optionally, hydroquinone or its derivatives and other skin lighteners may also be employed in the peel when conditions warrant.DESCRIPTION OF RELATED ART[0003] Skin peels are classified into three general types: light or superficial, medium and deep.[0004] The deep peel utilizes phenol as a primary ingredient. Phenol (C.sub.6H.sub.5OH) obtained from coal tar and also c...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/365A61K8/49A61K31/045A61K31/19A61K31/35A61K31/60A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/365A61K8/498A61Q19/08A61Q19/00A61Q19/02A61K2800/28
Inventor ANCIRA, MARGARET M.
Owner PHYSICIANS CHOICE OF ARIZONA
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